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Titolo:
EVALUATION OF LIVE, COLD-ADAPTED INFLUENZA-A AND INFLUENZA-B VIRUS-VACCINES IN ELDERLY AND HIGH-RISK SUBJECTS
Autore:
TREANOR JJ; BETTS RF;
Indirizzi:
UNIV ROCHESTER,INFECT DIS UNIT,BOX 689,601 ELMWOOD AVE ROCHESTER NY 14642
Titolo Testata:
Vaccine
fascicolo: 18, volume: 16, anno: 1998,
pagine: 1756 - 1760
SICI:
0264-410X(1998)16:18<1756:EOLCIA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONICALLY ILL ADULTS; A-VIRUS; ANTIBODY-RESPONSES; VACCINATION; OLDER; SERUM;
Keywords:
INFLUENZA; LIVE ATTENUATED VACCINE; ELDERLY; CLINICAL TRIALS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
J.J. Treanor e R.F. Betts, "EVALUATION OF LIVE, COLD-ADAPTED INFLUENZA-A AND INFLUENZA-B VIRUS-VACCINES IN ELDERLY AND HIGH-RISK SUBJECTS", Vaccine, 16(18), 1998, pp. 1756-1760

Abstract

We have evaluated the use of live cold-adapted influenza A and B virus vaccines in the elderly. Cold-adapted influenza A and B virus vaccines are safe and modestly immunogenic in individuals over 65 years of age. However; our studies and those of other groups have shown that immune response to cold-adapted vaccines in this age group are modest. Administration of combined cold-adapted influenza A and inactivated influenza vaccine has resulted in slightly higher frequencies of local andsystemic humoral immune responses than inactivated vaccine alone in some, but not all, studies. In a double-blind field trial conducted in nursing homes over a 3 year period, combined cold-adapted influenza A (H3N2) and trivalent inactivated influenza vaccine resulted in a 60% decrease (95% CI, 18-82%) in the rate of laboratory documented influenza A compared with inactivated vaccine alone. Further studies of multivalent cold-adapted influenza vaccines used in combination with inactivated vaccine should be performed. (C) 1998 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/08/20 alle ore 14:27:22