Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
THE HUMAN SURFEIT LOCUS
Autore:
DUHIG T; RUHRBERG C; MOR O; FRIED M;
Indirizzi:
IMPERIAL CANC RES FUND,EUKARYOT GENE ORG,44 LINCOLNS INN FIELDS LONDON WC2A 3PX ENGLAND IMPERIAL CANC RES FUND,EUKARYOT GENE ORG LONDON WC2A 3PX ENGLAND IMPERIAL CANC RES FUND,EXPRESS LAB LONDON WC2A 3PX ENGLAND
Titolo Testata:
Genomics (San Diego, Calif.)
fascicolo: 1, volume: 52, anno: 1998,
pagine: 72 - 78
SICI:
0888-7543(1998)52:1<72:>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
TIGHTLY CLUSTERED GENES; BIDIRECTIONAL PROMOTER; MESSENGER-RNAS; SURF-2 GENES; MOUSE; PROTEIN; ORGANIZATION; ENCODES; TRANSCRIPTION; CONSERVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
T. Duhig et al., "THE HUMAN SURFEIT LOCUS", Genomics (San Diego, Calif.), 52(1), 1998, pp. 72-78

Abstract

The organization of the human Surfeit locus containing the six sequence-unrelated housekeeping genes Surf-1 to Surf-6 (HGMW-approved symbols SURF1-SURF6) has been determined, The human surfeit locus occupies about 60 kb of DNA, and the tightly clustered gene organization and thejuxtaposition of the human genes are similar to the mouse and chickensurfeit loci with the 5' end of each gene associated with a CpG-rich island. Whereas in the mouse the Surf-2 and Surf-4 genes overlap at their 3' ends, the human Surf-a and Surf-4 genes have been found to be separated by 302 Bop due to a much shorter 3' ultranslated region in the human Surf-2 gene. The distance between the 3' ends of the human Surf-1 and Surf-3 genes is 374 bp, and the distance between the 5' ends of the human Surf-3 and Surf-5 genes is only 112 bp. Unusually the human Surf-Fl gene contains am intron in its 5' untranslated region slot found in the mouse or rat Surf-5 genes. This additional intron is also found in the Surf-5 gene of both Old and New World monkeys, being generated before the divergence of human and prosimians but after the divergence of primates and rodents. A contig of 200 kb containing the human Surfeit locus has been constructed from overlapping proximal, P1, and PAC clones, Approximately 40 kb proximal to the 3' end of the Surf-Ggene, the 5' region of the ABO glycosyltransferase gene has beets detected. This allows us to determine the orientation of the Surfeit and ABO loci with respect to each other and to the telomere and centromereof human chromosome 9. (C) 1998 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 14:59:22