Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
GROWTH-HORMONE INCREASES VERTEBRAL AND FEMORAL BONE STRENGTH IN OSTEOPENIC, OVARIECTOMIZED, AGED RATS IN A DOSE-DEPENDENT AND SITE-SPECIFICMANNER
Autore:
MOSEKILDE L; THOMSEN JS; ORHII PB; KALU DN;
Indirizzi:
UNIV AARHUS,INST ANAT,DEPT CELL BIOL DK-8000 AARHUS C DENMARK UNIV TEXAS,HLTH SCI CTR,DEPT PHYSIOL SAN ANTONIO TX 78284
Titolo Testata:
Bone (New York, N.Y.)
fascicolo: 4, volume: 23, anno: 1998,
pagine: 343 - 352
SICI:
8756-3282(1998)23:4<343:GIVAFB>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIRESORPTIVE AGENTS ESTROGEN; LONG-TERM EXERCISE; PARATHYROID-HORMONE; CORTICAL BONE; BIOMECHANICAL COMPETENCE; TRABECULAR BONE; SEXUALLY MATURE; MASS; FLUORIDE; MODEL;
Keywords:
RAT MODEL; OVARIECTOMY; OSTEOPENIA; GROWTH HORMONE; BONE MASS; BONE STRENGTH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
55
Recensione:
Indirizzi per estratti:
Citazione:
L. Mosekilde et al., "GROWTH-HORMONE INCREASES VERTEBRAL AND FEMORAL BONE STRENGTH IN OSTEOPENIC, OVARIECTOMIZED, AGED RATS IN A DOSE-DEPENDENT AND SITE-SPECIFICMANNER", Bone (New York, N.Y.), 23(4), 1998, pp. 343-352

Abstract

The aim of the study was to assess the effect of growth hormone (GH) as restorative therapy in an aged, ovariectomized rat model with established osteopenia, The study was planned as a dose-response study, andfour different skeletal sites were investigated by mechanical testingand measurements of hone mass and dimensions. Twelve-month-old virginF344 rats were divided into eight groups with ten animals per group: (1) sham operated (sham); (2) ovariectomized (ovx); (3) sham + solventvehicle (sv); (4) ovx + sv; (5) ovx + GH 50 mu g/kg body weight/day; (6) ovx + GH 1.25 mg/kg body weight/day; (7) ovx + GH 2.5 mg/kg body weight/day; and (8) ovx + GH 5.0 mg/kg body weight/day. Groups 1 and 2 were killed after 3 months to establish that bone loss had occurred due to ovx, One month later, the remaining groups began 3 months of treatment, at the end of which the animals were also killed. The effects of ovariectomy (ovx) and GH therapy were measured at four skeletal sites: lumbar vertebrae; femoral diaphysis; femoral neck; and distal femoral metaphysis, Ovariectomy induced a significant loss of bone strengthat all sites apart from the femoral neck, The loss was most pronounced at the distal femoral metaphysis, GH was able to reverse the ovx-induced loss of strength at the vertebral site in a dose-dependent manner. At the femoral diaphyseal site, GH not only reversed the ovx-inducedchanges but increased load values significantly above sham level. However, at the distal femoral metaphysis, which is dominated by cancellous bone, only partial reversal was seen after GH treatment. The lowestGH dose had no significant effect at any site tested. We conclude that GH treatment can reestablish vertebral bone loss due to ovariectomy in a dose-dependent manner. The restorative effect is only partial at the distal femoral metaphysis even at a high dose. At skeletal sites with less pronounced ovx-induced bone loss (femoral neck and diaphysis), GH treatment increased bone strength to sham level or above sham level. Therefore, the effect of ovariectomy is dependent upon the skeletal site investigated, and the effect of GH treatment is dependent on both the skeletal site and the size of the ovx-induced bone loss at thissite. (C) 1998 by Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 08:06:53