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Titolo:
GASTRIN-PRODUCING ENDOCRINE-CELLS - A NOVEL SOURCE OF HISTAMINE IN THE RAT STOMACH
Autore:
HUNYADY B; ZOLYOMI A; HOFFMAN BJ; MEZEY E;
Indirizzi:
NINCDS,BNP,NIH,BLDG 36 RM 3A17,9000 ROCKVILLE PIKE BETHESDA MD 20892 NIMH,NIH BETHESDA MD 20892 NICHHD,NIH BETHESDA MD 20892 UNIV PECS,DEPT MED 1 H-7643 PECS HUNGARY
Titolo Testata:
Endocrinology
fascicolo: 10, volume: 139, anno: 1998,
pagine: 4404 - 4415
SICI:
0013-7227(1998)139:10<4404:GE-ANS>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
VESICULAR MONOAMINE TRANSPORTER; HISTIDINE-DECARBOXYLASE; GASTROINTESTINAL-TRACT; ACID-SECRETION; NERVOUS-SYSTEM; SUBSTANCE-P; MAST-CELLS; NEURONS; EXPRESSION; ANTISERA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
B. Hunyady et al., "GASTRIN-PRODUCING ENDOCRINE-CELLS - A NOVEL SOURCE OF HISTAMINE IN THE RAT STOMACH", Endocrinology, 139(10), 1998, pp. 4404-4415

Abstract

Gastrin and histamine both potently stimulate secretion of acid into the gastric lumen. How these agents interact and how their release is controlled is poorly understood. Therefore, we decided to look for histamine in the antral portion of the rat stomach where the gastrin-producing G cells are located. We used immunocytochemical methods to visualize histamine, histidine decarboxylase (HDC, the enzyme that convertshistidine to histamine), and the type 1 vesicular monoamine transporter (VMAT1, the protein responsible for moving histamine into vesicles for storage and release). We were surprised to find that histamine, HDC, and VMAT1 were all present in G cells. Our results suggest that G cells synthesize and secrete gastrin and histamine. Whether histamine acts in concert with gastrin to stimulate acid secretion, or functions as an autocrine inhibitor of gastrin release remains to be seen.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/05/20 alle ore 14:24:53