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Titolo:
ATHEROGENIC LIPOPROTEINS INHIBIT CATECHOLAMINE SECRETION IN CULTURED BOVINE ADRENAL-MEDULLARY CELLS
Autore:
KAJIWARA K; YANAGIHARA N; TSUTSUI M; YASHIRO A; TASAKI H; NAKASHIMA Y; IZUMI F;
Indirizzi:
UNIV OCCUPAT & ENVIRONM HLTH,SCH MED,DEPT PHARMACOL,YAHATANISHI KU,1-1 ISEIGAOKA KITAKYUSHU FUKUOKA 8078555 JAPAN UNIV OCCUPAT & ENVIRONM HLTH,SCH MED,DEPT PHARMACOL,YAHATANISHI KU KITAKYUSHU FUKUOKA 8078555 JAPAN UNIV OCCUPAT & ENVIRONM HLTH,SCH MED,DEPT INTERNAL MED 2 KITAKYUSHU FUKUOKA 807 JAPAN
Titolo Testata:
Naunyn-Schmiedeberg's archives of pharmacology
fascicolo: 3, volume: 358, anno: 1998,
pagine: 308 - 314
SICI:
0028-1298(1998)358:3<308:ALICSI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY LIPOPROTEINS; PROTEIN-KINASE-II; ACTIVATION; CHANNELS; LEVEL;
Keywords:
ADRENAL MEDULLARY CELLS; APOLIPOPROTEIN B FRAGMENT(3358-3372)-AMIDE CATECHOLAMINE SECRETION; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; LIPOPROTEIN(A); NICOTINIC ACETYLCHOLINE RECEPTOR-ION CHANNEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
K. Kajiwara et al., "ATHEROGENIC LIPOPROTEINS INHIBIT CATECHOLAMINE SECRETION IN CULTURED BOVINE ADRENAL-MEDULLARY CELLS", Naunyn-Schmiedeberg's archives of pharmacology, 358(3), 1998, pp. 308-314

Abstract

The effects of lipoproteins on ion channel-mediated catecholamine secretion were investigated in cultured bovine adrenal medullary cells. Low density lipoprotein (LDL, 20-80 mg/dl) and lipoprotein(a) [Lp(a); 10-80 mg/dl] inhibited catecholamine secretion induced by carbachol, anactivator of nicotinic acetylcholine receptor-ion channels. LDL and Lp(a) suppressed carbachol-induced Na-22(+) influx as well as Ca-45(2+)influx in a concentration-dependent manner similar to that of catecholamine secretion. The inhibition of catecholamine secretion by Lp(a) was not overcome by increasing the concentration of carbachol. On the other hand, high density lipoprotein (HDL; <150 mg/dl) had no effect onNa-22(+) influx, Ca-45(2+) influx, and catecholamine secretion. Like LDL and Lp(a), a synthetic peptide homologous to human plasma apolipoprotein B (apoB), apoB fragment(3358-3372)-amide (3-60 mu M), attenuated Na-22(+) influx, Ca-45(2+) influx, and catecholamine secretion caused by carbachol. The apoB fragment also suppressed Na-22(+) influx induced by veratridine tan activator of voltage-dependent Na+ channels) and Ca-45(2+) influx induced by 56 mM K+ tan indirect activator of voltage-dependent Ca2+ channels). These findings suggest that atherogenic lipoproteins such as LDL and Lp(a) suppress catecholamine secretion by interfering with Naf influx through nicotinic acetylcholine receptor-ion channels, in which apoB, a structural component common to both LDL and Lp(a), plays an important role. The inhibition by atherogenic lipoproteins of catecholamine secretion may influence the progression of atherosclerosis induced by these lipoproteins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 00:08:01