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Titolo:
ROLE OF CYTOKINES IN THE MAINTENANCE OF THE MEMORY IMMUNE-RESPONSE INDUCED BY A RAT HISTIOCYTOMA IN SYNGENEIC HOSTS
Autore:
NANDAKUMAR KS; VARALAKSHMI C; KHAR A;
Indirizzi:
CTR CELLULAR & MOL BIOL HYDERABAD 500007 ANDHRA PRADESH INDIA CTR CELLULAR & MOL BIOL HYDERABAD 500007 ANDHRA PRADESH INDIA
Titolo Testata:
Cytokines cellular & molecular therapy
fascicolo: 3, volume: 4, anno: 1998,
pagine: 169 - 175
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER-CELL; AK-5 TUMOR; IMMUNOLOGICAL MEMORY; INTERFERON-GAMMA; NK CELLS; T-CELLS; REGRESSION; INTERLEUKIN-12; DEATH; EXPRESSION;
Keywords:
CYTOKINES; TUMOR REGRESSION; IMMUNE MEMORY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
K.S. Nandakumar et al., "ROLE OF CYTOKINES IN THE MAINTENANCE OF THE MEMORY IMMUNE-RESPONSE INDUCED BY A RAT HISTIOCYTOMA IN SYNGENEIC HOSTS", Cytokines cellular & molecular therapy, 4(3), 1998, pp. 169-175

Abstract

The nature of immune memory induced by a rat histiocytoma, AK-5, in syngeneic hosts was studied. AK-5 tumor when transplanted intraperitoneally (i.p.) into naive animals grows as ascites and is 100% fatal. However, spontaneous regression of AK-5 tumor was observed in 60% of animals upon s.c. transplantation. Interestingly, all the tumor-rejected animals (immune) were found to resist further i.p, challenges with AK-5cells. The immunity thus developed is specific for AK-5 tumor, since other tumors grow in these animals. In order to understand the tumor-specific immune memory induced after AK-5 tumor transplantation, we have evaluated circulatory-cytokine profiles of i.p, tumor-transplanted naive and Immune animals. Our results show an increase in the levels ofIL-2, IL-12 and IL-4 in tumor-injected immune animals compared with normal animals, whereas the interferon-gamma levels were totally reversed in these two sets of animals. We also found elevated levers of circulating immune complexes in the sera from AK-5-rechallenged Immune animals. We have also evaluated the cytotoxic potential of splenocytes and pure natural killer cells from immune animals rechallenged with AK-5cells, and have found a significant increase in antibody-dependent cellular cytotoxicity. similarly, in vitro proliferation of total splenocytes and nylon-wool non-adherent cells from immune animals was much higher compared with the normal animals. The present study thus suggests antigen-independent maintenance of clonal burst size, which could bethe form of immune memory induced by AK-5 tumor in the syngeneic host.

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Documento generato il 02/07/20 alle ore 17:50:44