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Titolo:
MICROSPHERE INFUSION REVERSES VASOCONSTRICTOR-MEDIATED CHANGE IN HINDLIMB OXYGEN-UPTAKE AND ENERGY STATUS
Autore:
VINCENT MA; RATTIGAN S; CLARK MG;
Indirizzi:
UNIV TASMANIA,SCH MED,DIV BIOCHEM,GPO BOX 252-58 HOBART TAS 7001 AUSTRALIA
Titolo Testata:
Acta Physiologica Scandinavica
fascicolo: 1, volume: 164, anno: 1998,
pagine: 61 - 69
SICI:
0001-6772(1998)164:1<61:MIRVCI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFUSED RAT HINDLIMB; MUSCLE; SEROTONIN; METABOLISM;
Keywords:
MICROEMBOLISM OF MUSCLE FLOW; NONNUTRITIVE FLOW; NUTRITIVE FLOW; 2 CIRCULATORY SYSTEMS IN MUSCLE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
M.A. Vincent et al., "MICROSPHERE INFUSION REVERSES VASOCONSTRICTOR-MEDIATED CHANGE IN HINDLIMB OXYGEN-UPTAKE AND ENERGY STATUS", Acta Physiologica Scandinavica, 164(1), 1998, pp. 61-69

Abstract

The vasoconstrictors, angiotensin II (All) and serotonin (5-HT) produce opposing metabolic effects and appear to control different flow routes in the constant-flow perfused rat hindlimb. In the present study the association between vascular flow route recruitment and metabolism was assessed by selective microsphere embolism of either route. Microspheres (MS, 11.9 +/- 0.1 mu m, mean +/- SE diameter) were injected during All, 5-HT or vehicle infusions(basal conditions) and the effects on hindlimb (4.7 +/- 0.1 g muscle) oxygen uptake ((C) over dot o(2)) and indices of energy status CrP/Cr, CrP/ATP and energy charge (EC) of the calf muscle group assessed. MS (1.5 x 10(6)) injected during vehicle, or 5-HT infusion increased (V) over dot o(2) (P < 0.05) but did notaffect energy status. During All, MS decreased (V) over dot o(2). Change in (V) over dot o(2) correlated positively with CrP/Cr (r = 0.68, P < 0.0001) and CrP/ATP (r = 0.51, P < 0.001) but not EC (r = 0.08, P = 0.59). MS (1.5 x 10(6)) increased pressure but did not affect the flow rate. The metabolic changes resulting from 1.5 x 10(6) microsphereswere intensified by a second injection of 1.5 x 10(6) microspheres but further injection (>3.0 x 10(6) microspheres) began to inhibit flow. It is concluded that a finite number (less than or equal to 3.0 x 10(6)) of microspheres of 11.9 mu m diameter has opposite effects on (C) over dot o(2) depending on the vasoconstrictor present and that these effects result from the occlusion of the different vascular route accessed by each vasoconstrictor. The data support the proposal that hindlimb metabolism can be controlled by vasoconstrictors as a result of selective vascular recruitment.

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Documento generato il 27/11/20 alle ore 15:25:40