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Titolo:
PRESYNAPTIC DOPAMINE FUNCTION IN STRIATUM OF NEUROLEPTIC-NAIVE SCHIZOPHRENIC-PATIENTS
Autore:
HIETALA J; SYVALAHTI E; VUORIO K; RAKKOLAINEN V; BERGMAN J; HAAPARANTA M; SOLIN O; KUOPPAMAKI M; KIRVELA O; RUOTSALAINEN U; SALOKANGAS RKR;
Indirizzi:
UNIV TURKU,DEPT PHARMACOL,KIINAMYLLYNKATU 10 SF-20520 TURKU FINLAND TURKU MED CYCLOTRON PET PROJECT TURKU FINLAND TURKU CITY PSYCHIAT HOSP TURKU FINLAND ABO AKAD UNIV,ACCELERATOR LAB TURKU FINLAND TURKU UNIV HOSP,DEPT ANAESTHESIOL SF-20520 TURKU FINLAND TURKU UNIV HOSP,DEPT PSYCHIAT SF-20520 TURKU FINLAND
Titolo Testata:
Lancet
fascicolo: 8983, volume: 346, anno: 1995,
pagine: 1130 - 1131
SICI:
0140-6736(1995)346:8983<1130:PDFISO>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; ABNORMALITIES; RECEPTORS;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
10
Recensione:
Indirizzi per estratti:
Citazione:
J. Hietala et al., "PRESYNAPTIC DOPAMINE FUNCTION IN STRIATUM OF NEUROLEPTIC-NAIVE SCHIZOPHRENIC-PATIENTS", Lancet, 346(8983), 1995, pp. 1130-1131

Abstract

Presynaptic dopamine function (6-[F-18]-fluorodopa uptake) in the brains of seven neuroleptic-naive first-admission schizophrenic patients and eight healthy controls was studied with positron emission tomography. The fluorodopa influx constant (K-i) in putamen was higher in the patients than in controls (average mean: 0.0149 vs 0.0129, p=0.034). The changes in caudate were smaller but significantly lateralised to the left caudate. There was one catatonic schizophrenic patient in our sample. This patient had lower striatal K-i than any control. Alterations in striatal presynaptic dopamine function may constitute a part of disrupted neural circuits that predispose to schizophrenic psychosis.

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Documento generato il 06/04/20 alle ore 08:23:05