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Titolo:
PEDIATRIC LOW-GRADE GLIOMAS - PROGNOSIS WITH PROTON MAGNETIC-RESONANCE SPECTROSCOPIC IMAGING
Autore:
LAZAREFF JA; BOCKHORST KHJ; CURRAN J; OLMSTEAD C; ALGER JR;
Indirizzi:
UNIV CALIF LOS ANGELES,SCH MED,DIV NEUROSURG,BOX 957039 LOS ANGELES CA 90095 UNIV CALIF LOS ANGELES,DEPT SURG LOS ANGELES CA 90095 UNIV CALIF LOS ANGELES,DEPT RADIOL SCI LOS ANGELES CA 90095
Titolo Testata:
Neurosurgery
fascicolo: 4, volume: 43, anno: 1998,
pagine: 809 - 817
SICI:
0148-396X(1998)43:4<809:PLG-PW>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN BRAIN-TUMORS; JUVENILE PILOCYTIC ASTROCYTOMAS; POSITRON EMISSION TOMOGRAPHY; IN-VITRO; MR SPECTROSCOPY; HYPOTHALAMIC GLIOMAS; CEREBRAL HEMISPHERES; OPTIC PATHWAY; H-1 MRS; VIVO;
Keywords:
BRAIN; LOW-GRADE GLIOMA; MAGNETIC RESONANCE SPECTROSCOPY; PROGNOSIS; TUMOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Lazareff et al., "PEDIATRIC LOW-GRADE GLIOMAS - PROGNOSIS WITH PROTON MAGNETIC-RESONANCE SPECTROSCOPIC IMAGING", Neurosurgery, 43(4), 1998, pp. 809-817

Abstract

OBJECTIVE: Our aim was to assess the correlation between the low-grade glioma (LGG) metabolic profile and tumor progression. Using in vivo proton magnetic resonance spectroscopic imaging, we specifically askedwhether and which metabolic features are associated with tumor regrowth or recurrence. METHODS: Eleven pediatric patients with histologically proven partially resected (<20% resection) midline LGG were treatedand followed up for a period of 2 years. All patients underwent proton magnetic resonance spectroscopic imaging studies before any management was determined. Tumor progression was defined as radiological evidence of mass enlargement (>25%) during the follow-up period. Proton magnetic resonance spectroscopic imaging was performed using a PRESS-CSI sequence on a General Electric 1.5-tesla scanner (General Electric Medical System, Waukesha, WI). The signal intensities of N-acetylaspartate, choline (CHO), and creatine from the tumor and the normal brain were used to calculate normalized metabolite intensities and metabolite ratios. RESULTS: Tumors that progressed during a 2-year period displayed higher normalized CHO than those that remained stable (Mann-Whitney test, P < 0.03). The majority (five of six) of the rapidly growing LGGshowed values of normalized CHO of at least 1, whereas the nonprogressors had a normalized CHO value of less than 1. CONCLUSION: In association with pediatric LGG, high normalized CHO values seem to herald thepotential for rapid tumor growth. These observations may be valuable for defining subsets of patients with LGG who may benefit from early therapeutic interventions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:40:02