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Titolo:
PROGRESS TOWARDS A NEW TUBERCULOSIS VACCINE
Autore:
LOWRIE DB; SILVA CL; TASCON RE;
Indirizzi:
NATL INST MED RES,MILL HILL,THE RIDGEWAY LONDON NW7 1AA ENGLAND UNIV SAO PAULO SAO PAULO BRAZIL
Titolo Testata:
Biodrugs
fascicolo: 3, volume: 10, anno: 1998,
pagine: 201 - 213
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYCOBACTERIUM-BOVIS BCG; HEAT-SHOCK PROTEIN; BACILLUS-CALMETTE-GUERIN; T-CELL RESPONSES; IMMUNODEFICIENCY-VIRUS TYPE-1; PROTECTIVE IMMUNE-RESPONSES; DNA IMMUNIZATION; PLASMID DNA; PULMONARY TUBERCULOSIS; ADJUVANT ARTHRITIS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
149
Recensione:
Indirizzi per estratti:
Citazione:
D.B. Lowrie et al., "PROGRESS TOWARDS A NEW TUBERCULOSIS VACCINE", Biodrugs, 10(3), 1998, pp. 201-213

Abstract

New weapons are needed in the fight against tuberculosis, both antibacterial drugs and a vaccine. If one new antituberculosis drug is developed it will encounter emerging resistance; at least two are needed, to be used in combination only. This is a complicated and difficult goal. In contrast, an effective new vaccine would have multiple antigenictargets within the bacterium, making the emergence of resistance to the vaccine unlikely. This is a simpler goal to achieve, and recent research indicates that it may be within reach. A diverse range of protein antigens can give encouragingly high levels of protective immunity in animal models when administered with adjuvants or as DNA vaccines. Accelerated arrest of bacterial multiplication, followed by sustained decline in bacterial numbers, are key parameters of protection; the vaccine must target antigens produced by actively multiplying bacteria aswell as growth-inhibited bacteria. Consistent with this, the protective antigens have been found among secreted and stress proteins (for example Ag85, ESAT-6, hsp65, hsp70). Species-specific antigens are not required, so these remain available for diagnostic tests. Adoptive transfer of protection from vaccinated or infected mice into naive mice bytransfer of purified T cells and clones shows that protection is expressed by antigen-specific cytotoxic T cells that produce interferon-gamma and lyse infected macrophages. These cells are produced in response to endogenous antigen. DNA vaccination appears to be superior to recombinant mycobacterial or viral vectors for this purpose.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/10/20 alle ore 10:38:54