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Titolo:
ENHANCEMENT OF ANTIPSYCHOTICLIKE PROPERTIES OF RACLOPRIDE IN RATS USING THE SELECTIVE SEROTONIN(2A) RECEPTOR ANTAGONIST MDL-100,907
Autore:
WADENBERG MLG; HICKS PB; RICHTER JT; YOUNG KA;
Indirizzi:
KAROLINSKA INST,DEPT PHYSIOL & PHARMACOL S-17177 STOCKHOLM SWEDEN SCOTT SHERWOOD & BRINDLEY FDN,SCOTT & WHITE CLIN & MEM HOSP,DEPT PSYCHIAT TEMPLE TX 00000 CENT TEXAS VET HLTH CARE SYST,NEUROSCI LAB WACO TX 00000 TEXAS A&M UNIV,CTR HLTH SCI,COLL MED COLLEGE STN TX 00000
Titolo Testata:
Biological psychiatry
fascicolo: 6, volume: 44, anno: 1998,
pagine: 508 - 515
SICI:
0006-3223(1998)44:6<508:EOAPOR>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEGATIVE SYMPTOMS; SCHIZOPHRENIA; RITANSERIN; AVOIDANCE; PHARMACOLOGY; RISPERIDONE; INHIBITION; CLOZAPINE; BEHAVIOR; INVITRO;
Keywords:
DOPAMINE D-2 RECEPTOR; SEROTONIN(2A) RECEPTOR; CONDITIONED AVOIDANCE RESPONSE BEHAVIOR; ATYPICAL ANTIPSYCHOTIC DRUGS; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
M.L.G. Wadenberg et al., "ENHANCEMENT OF ANTIPSYCHOTICLIKE PROPERTIES OF RACLOPRIDE IN RATS USING THE SELECTIVE SEROTONIN(2A) RECEPTOR ANTAGONIST MDL-100,907", Biological psychiatry, 44(6), 1998, pp. 508-515

Abstract

Background: Selective suppression of conditioned avoidance response (CAR) is a standard animal screening test for predicting antipsychotic effect Ability to suppress CAR is presumed to be due to antagonism at dopamine receptors, a property shared by all known antipsychotics, Methods: Using CAR behavior, in a conventional shuttle-box paradigm, as an index for antipsychotic efficacy, the effects of the selective serotonin, receptor antagonist MDL 100,907 alone, and in combination with the dopamine D-2 receptor antagonist raclopride, were studied in adult male Sprague-Dawley rats. Nonparametric procedures were employed for statistical evaluation. Results: MDL 100,907 (0.1-1.5 mg/kg, SC) alone did not suppress CAR in a manner predictive of antipsychotic activity:however, in the presence of an ED50 (0.14 mg/kg, SC) dose of raclopride, MDL 100,907 enhanced and prolonged the suppression of CAR. In the presence of a subthreshold (0.05 mg/kg, SC) dose of raclopride, MDL 100,907 induced a suppression of CAR. Conclusions: The results suggest that treatment with a selective serotonin(2A) receptor antagonist alonemay nor produce a robust antipsychotic effect; however, a selective serotonin(2A) receptor antagonist in the presence of a minimal dopamineD-2 receptor blocking action could potentially be an adjunctive therapy resulting in improved antipsychotic efficacy and fewer extrapyramidal symptoms. (C) 1998 Society of Biological Psychiatry.

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Documento generato il 17/01/20 alle ore 20:24:15