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Titolo:
RANDOMIZED TRIAL OF THE EFFECT OF SUPPLEMENTATION ON THE COGNITIVE FUNCTION OF OLDER-PEOPLE WITH SUBNORMAL COBALAMIN LEVELS
Autore:
KWOK T; TANG C; WOO J; LAI WK; LAW LK; PANG CP;
Indirizzi:
PRINCE WALES HOSP,DEPT MED SHATIN HONG KONG CHINESE UNIV HONG KONG,DEPT MED HONG KONG HONG KONG CHINESE UNIV HONG KONG,DEPT PSYCHOL HONG KONG HONG KONG CHINESE UNIV HONG KONG,DEPT CHEM PATHOL HONG KONG HONG KONG
Titolo Testata:
International journal of geriatric psychiatry
fascicolo: 9, volume: 13, anno: 1998,
pagine: 611 - 616
SICI:
0885-6230(1998)13:9<611:RTOTEO>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEALTHY ELDERLY POPULATION; SERUM METHYLMALONIC ACID; VITAMIN-B12 DEFICIENCY; ALZHEIMERS-DISEASE; DIAGNOSIS; DEMENTIA; FOLATE;
Keywords:
COBALAMIN; VITAMIN B12; SUPPLEMENTATION; COGNITIVE; ELDERLY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
T. Kwok et al., "RANDOMIZED TRIAL OF THE EFFECT OF SUPPLEMENTATION ON THE COGNITIVE FUNCTION OF OLDER-PEOPLE WITH SUBNORMAL COBALAMIN LEVELS", International journal of geriatric psychiatry, 13(9), 1998, pp. 611-616

Abstract

Background. Low serum cobalamin levels are often found in apparently normal older subjects. A major worry of leaving cobalamin deficiency untreated is that it may lead to subtle deterioration in cognitive function. Objectives. To investigate the effect of supplementation on the cognitive function of older people with cobalamin deficiency by a randomized trial. Methods. Fifty Chinese subjects more than 60 years old with serum cobalamin level < 120 pmol/l were randomized into supplementand control groups. Fasting serum methylmalonic acid levels (MMA) were measured. A battery of neuropsychological tests was administered. The supplement group received intramuscular cyanocobalamin injections, while the control group received no intervention. They were followed upat around 4 months. Results. 78% of the subjects had raised MMA, indicating metabolic cobalamin deficiency. Supplemented subjects improved in performance IQ, but the amount of improvement was not significantlymore than that of control subjects. Moreover, the supplement group fared worse than the control group at follow-up in some motor function scores. Three out of seven demented subjects had improvement in Mini-Mental State Examination scores, but there was no consistent improvementin other neuropsychological scores. Conclusions. This study suggestedthat cobalamin deficiency did not invariably cause cognitive impairment in older people. There remain the possibilities that cobalamin deficiency causes cognitive impairment or exacerbates coexisting dementia in some older people. (C) 1998 John Wiley & Sons, Ltd.

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Documento generato il 06/04/20 alle ore 08:29:08