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Titolo:
SQUAMOUS-CELL CARCINOMAS AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATIONFOR APLASTIC-ANEMIA - FURTHER EVIDENCE OF A MULTISTEP PROCESS
Autore:
SOCIE G; SCIEUX C; GLUCKMAN E; SOUSSI T; CLAVEL C; SAULNIER P; BIREMBAULT P; BOSQ J; MORINET F; JANIN A;
Indirizzi:
HOP ST LOUIS,SERV HEMATOL GREFFE MOELLE,VIROL LAB,1 AVE CLAUDE VELLEFAUX F-75475 PARIS 10 FRANCE HOP ST LOUIS,UNITE RECH BIOL CELLULES SOUCHES F-75475 PARIS 10 FRANCE HOP ST LOUIS,SERV ANAT PATHOL F-75475 PARIS 10 FRANCE HOP ST LOUIS,LAB RECH UNIV PATHOL F-75475 PARIS 10 FRANCE INST CURIE,LAB GENOTOXICOL & MODULAT EXPRESS GEN,UMR 218,CNRS PARIS FRANCE CHU MAISON BLANCHE,LAB POL BOUIN,UNITE BIOL CELLULAIRE & MOL REIMS FRANCE INST GUSTAVE ROUSSY,SERV MICROBIOL MED VILLEJUIF FRANCE INST GUSTAVE ROUSSY,SERV HISTOPATHOL A VILLEJUIF FRANCE
Titolo Testata:
Transplantation
fascicolo: 5, volume: 66, anno: 1998,
pagine: 667 - 670
SICI:
0041-1337(1998)66:5<667:SCAABT>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; EPSTEIN-BARR-VIRUS; KAPOSIS-SARCOMA; DNA-SEQUENCES; FANCONI-ANEMIA; P53 MUTATIONS; SKIN-LESIONS; HERPESVIRUS; CANCER; IDENTIFICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
G. Socie et al., "SQUAMOUS-CELL CARCINOMAS AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATIONFOR APLASTIC-ANEMIA - FURTHER EVIDENCE OF A MULTISTEP PROCESS", Transplantation, 66(5), 1998, pp. 667-670

Abstract

Background. Secondary solid tumors are rare events occurring in patients who underwent allogeneic marrow transplantation for aplastic anemia and Fanconi's anemia. Human herpes virus 8 (HHV8), Epstein-Barr virus (EBV), and human papillomaviruses (HPV) sequences have been found insquamous cell carcinoma (SCC) occurring in organ transplant recipients. The tumor suppressor gene p53 has been strongly linked to the occurrence of SCC in the nonimmunocompromised population. Patients and methods. In eight patients with SCC, we searched for HHV8, EBV, varicella tester virus, adenovirus, and HPV sequences from DNA extracted from selected areas of SCC, We also looked for p53 expression in those specimens as well as the presence of anti-p53 antibodies in the serum of these patients at the onset of SCC. Results. In one patient, we found thepresence of both HHV8 and EBV sequences, and in another patient we found HPV16 sequences. All five tumors that could be studied disclosed evidence of p53 accumulation, but none of the eight patients had anti-p53 antibodies in the sera. Conclusion. SCC developing in marrow transplant recipients seems to occur via a multistep process. Genetic predisposition may be present, as in patients with Fanconi's anemia, Transplantation-related factors, such as irradiation and chronic graft-versus-host disease, also have a role. In this article, we add two more potent risk factors: p53 alteration(s) and in some cases the presence of oncogenic viruses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 04:30:48