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Titolo:
VOLATILE ANESTHETICS REDUCE ADHESION OF BLOOD-PLATELETS UNDER LOW-FLOW CONDITIONS IN THE CORONARY SYSTEM OF ISOLATED GUINEA-PIG HEARTS
Autore:
HEINDL B; BECKER BF; ZAHLER S; CONZEN PF;
Indirizzi:
UNIV MUNICH,INST PHYSIOL,PETTENKOFERSTR 12 D-80336 MUNICH GERMANY UNIV MUNICH,KLINIKUM GROSSHADERN,INST ANAESTHESIOL D-8000 MUNICH GERMANY
Titolo Testata:
Acta anaesthesiologica Scandinavica
fascicolo: 8, volume: 42, anno: 1998,
pagine: 995 - 1003
SICI:
0001-5172(1998)42:8<995:VARAOB>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYOCARDIAL-INFARCTION; VON-WILLEBRAND-FACTOR; DIRECTIONAL ATHERECTOMY; FENTANYL ANESTHESIA; THROMBUS FORMATION; NITROUS-OXIDE; EPIC TRIAL; RAT-HEART; AGGREGATION; ISOFLURANE;
Keywords:
ADHESION; HALOTHANE; ISOFLURANE; SEVOFLURANE; PLATELETS; THROMBOCYTES; CORONARY ENDOTHELIUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
B. Heindl et al., "VOLATILE ANESTHETICS REDUCE ADHESION OF BLOOD-PLATELETS UNDER LOW-FLOW CONDITIONS IN THE CORONARY SYSTEM OF ISOLATED GUINEA-PIG HEARTS", Acta anaesthesiologica Scandinavica, 42(8), 1998, pp. 995-1003

Abstract

Background: inhibitory effects of volatile anaesthetics on platelet aggregation have been demonstrated in several studies. However, the influence of volatile anaesthetics on intracoronary platelet adhesion hasnot been elucidated so far. Methods: Isolated hearts of guinea pigs were perfused with buffer in the absence or presence of volatile anaesthetics (0.5 and 1 MAC) at constant coronary flow rates of 5 ml/min for25 min, then 1 ml/min for 30 min and again 5 ml/min for 10 min. Before, during and after low-flow perfusion, a bolus of human platelets wasapplied into the coronary system. To simulate thrombogenic conditions, 0.3 U/ml human thrombin was infused during low-flow perfusion and reperfusion. The number of platelets sequestered to the endothelium was calculated from the difference between coronary in- and output of platelets. The myocardial production of lactate and consumption of pyruvate and coronary perfusion pressure were also determined. Results: At a flow rate of 5 ml/min only about 3% of the applied platelets did not emerge from the coronary system, in any group. In contrast, 13.1+/-1.2%(mean+/-SEM) of infused platelets became adherent in low-flow perfusion in the control group without anaesthetic. The adherence was reducedwith each 1 MAC isoflurane (to 6.2+/-1.2%), sevoflurane (to 4.4+/-0.9%) or halothane (to 3.2+/-1.5%) (each P<0.05 vs, control). Volatile anaesthetic, 0.5 MAC, did not inhibit platelet adhesion to a statistically significant extent in any case. Perfusion pressure and metabolic parameters were not statistically different between the control and the hearts exposed to anaesthetics. Conclusion: Volatile anaesthetics in aconcentration of 1 MAC can reduce the adhesion of platelets in the coronary system under reduced flow conditions. This action does not arise from vasodilation or inhibition of ischaemic stress.

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Documento generato il 03/04/20 alle ore 10:12:02