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Titolo:
DOES LIDOCAINE PROTECT THE HEART DURING CORONARY REVASCULARIZATION
Autore:
RINNE T; KAUKINEN S;
Indirizzi:
TAMPERE UNIV HOSP,DEPT ANAESTHESIA & INTENS CARE,POB 2000 FIN-33521 TAMPERE FINLAND SCH MED TAMPERE FINLAND
Titolo Testata:
Acta anaesthesiologica Scandinavica
fascicolo: 8, volume: 42, anno: 1998,
pagine: 936 - 940
SICI:
0001-5172(1998)42:8<936:DLPTHD>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYOCARDIAL-INFARCTION; CARDIAC SODIUM-CHANNELS; TROPONIN-T; VENTRICULAR-FIBRILLATION; CARDIOPLEGIA; RELEASE; ARRHYTHMIAS; ISCHEMIA;
Keywords:
CARDIOPLEGIC SOLUTIONS, BLOOD CARDIOPLEGIA; AORTOCORONARY BYPASS; CARDIOPROTECTION; LIDOCAINE; TROPONIN T;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
T. Rinne e S. Kaukinen, "DOES LIDOCAINE PROTECT THE HEART DURING CORONARY REVASCULARIZATION", Acta anaesthesiologica Scandinavica, 42(8), 1998, pp. 936-940

Abstract

Background: Lidocaine has been used as the primary antiarrhythmic agent for ventricular arrhythmias during acute myocardial infarction (MI)and open heart surgery. Its cardioprotective effects have been studied in experimental settings and also during angioplastic reperfusion and coronary revascularisation. The basic mechanism of action, probably also involved with cardioprotection, has been demonstrated to be blockade of cardiac sodium channels. In this open study we investigated thecontribution of continuous lidocaine infusion to cardioprotection during coronary revascularisation with blood cardioplegia. Methods: During coronary revascularisation with cold blood cardioplegia, a study group of 50 patients received a prophylactic Lidocaine infusion for 20 h started with a bolus dose before aortic clamping; another group of 50 patients without the infusion served as a control group. Serum troponin T concentration, serum creatine kinase MB activity and electrocardiography were the main parameters recorded. Results: Serial measurement of Troponin T (P=0.06) and CKMB values: (P=0.09) were slightly lower in the lidocaine group, but the differences were not statistically significant. Conclusion: Lacking statistically significant evidence of improved cardioprotection, lidocaine infusion cannot be recommended as a routine treatment during coronary revascularisation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 13:39:12