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Titolo:
IDENTIFICATION OF GERM-LINE E-CADHERIN MUTATIONS IN GASTRIC-CANCER FAMILIES OF EUROPEAN ORIGIN
Autore:
GAYTHER SA; GORRINGE KL; RAMUS SJ; HUNTSMAN D; ROVIELLO F; GREHAN N; MACHADO JE; PINTO E;
Indirizzi:
UNIV CAMBRIDGE,ADDENBROOKES HOSP,DEPT ONCOL CAMBRIDGE CB2 2QQ ENGLAND UNIV CAMBRIDGE,ADDENBROOKES HOSP,DEPT ONCOL CAMBRIDGE CB2 2QQ ENGLAND UNIV CAMBRIDGE,ADDENBROOKES HOSP,CANC RES CAMPAIGN,HUMAN CANC GENET RES GRP CAMBRIDGE CB2 2QQ ENGLAND UNIV SIENA,IST POLICATTEDRA SCI CHIRURG I-53100 SIENA ITALY UNIV OPORTO,IPATIMUP,INST PATOL & IMUNOL MOL P-4200 OPORTO PORTUGAL MAYO CLIN ROCHESTER MN 55905 VICTORIA GEN HOSP VICTORIA BC V8Z 6R5 CANADA UNIV VIRGINIA,HLTH SCI CTR,DEPT INTERNAL MED CHARLOTTESVILLE VA 22906 HENRY FORD HOSP DETROIT MI 48202
Titolo Testata:
Cancer research
fascicolo: 18, volume: 58, anno: 1998,
pagine: 4086 - 4089
SICI:
0008-5472(1998)58:18<4086:IOGEMI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
INVASION-SUPPRESSOR GENE; COLORECTAL-CANCER; STOMACH; CARCINOMAS; RISK; HISTORY; BREAST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
S.A. Gayther et al., "IDENTIFICATION OF GERM-LINE E-CADHERIN MUTATIONS IN GASTRIC-CANCER FAMILIES OF EUROPEAN ORIGIN", Cancer research, 58(18), 1998, pp. 4086-4089

Abstract

E-cadherin germ-line mutations have recently been described as a molecular basis for early-onset familial gastric cancer in Maori kindred. We screened 18 gastric cancer families of European origin for germ-line mutations to determine the proportion in which E-cadherin mutations occur and the clinical characteristics of the affected families. Truncating mutations were identified in three kindred with familial diffusegastric cancer. In these families, the age of onset of gastric cancerwas variable, the penetrance was incomplete, and one kindred contained individuals with cancers at other sites. Here, we show that a proportion of diffuse gastric cancer families of European origin have germ-line E-cadherin mutations; however, these mutations are absent in intestinal gastric cancer families.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 16:25:37