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Titolo:
CANNABINOID RECEPTOR ACTIVATION DIFFERENTIALLY REGULATES THE VARIOUS ADENYLYL-CYCLASE ISOZYMES
Autore:
RHEE MH; BAYEWITCH M; AVIDORREISS T; LEVY R; VOGEL Z;
Indirizzi:
WEIZMANN INST SCI,DEPT NEUROBIOL IL-76100 REHOVOT ISRAEL WEIZMANN INST SCI,DEPT NEUROBIOL IL-76100 REHOVOT ISRAEL
Titolo Testata:
Journal of neurochemistry
fascicolo: 4, volume: 71, anno: 1998,
pagine: 1525 - 1534
SICI:
0022-3042(1998)71:4<1525:CRADRT>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-GAMMA-SUBUNITS; RAT-BRAIN; SIGNALING PATHWAY; CALCIUM CHANNELS; G-PROTEINS; IN-VIVO; STIMULATION; EXPRESSION; CELLS; CAMP;
Keywords:
CANNABINOID RECEPTOR; FORSKOLIN; ADENYLYL CYCLASE; GTP-BINDING PROTEINS; CYCLIC AMP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
M.H. Rhee et al., "CANNABINOID RECEPTOR ACTIVATION DIFFERENTIALLY REGULATES THE VARIOUS ADENYLYL-CYCLASE ISOZYMES", Journal of neurochemistry, 71(4), 1998, pp. 1525-1534

Abstract

Two cannabinoid receptors belonging to the superfamily of G protein-coupled membrane receptors have been identified and cloned: the neuronal cannabinoid receptor (CB1) and the peripheral cannabinoid receptor (CB2). They have been shown to couple directly to the G(i/o) subclass of G proteins and to mediate inhibition of adenylyl cyclase upon binding of a cannabinoid agonist. In several cases, however, cannabinoids have been reported to stimulate adenylyl cyclase activity, although the mechanism by which they did so was unclear. With the cloning of nine adenylyl cyclase isozymes with various properties, including different sensitivities to alpha(s), alpha(i/o), and py subunits, it became important to assess the signaling pattern mediated by each cannabinoid receptor via the different adenylyl cyclase isozymes. In this work, we present the results of cotransfection experiments between the two types of cannabinoid receptors and the nine adenylyl cyclase isoforms. We found that independently of the method used to stimulate specific adenylyl cyclase isozymes (e.g., ionomycin, forskolin, constitutively activealpha(s), thyroid-stimulating hormone receptor activation), activation of the cannabinoid receptors CB1 and CB2 inhibited the activity of adenylyl cyclase types I, V, VI, and VIII, whereas types II, IV, and VII were stimulated by cannabinoid receptor activation. The inhibition of adenylyl cyclase type III by cannabinoids was observed only when forskolin was used as stimulant. The activity of adenylyl cyclase type IXwas inhibited only marginally by cannabinoids.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 00:58:55