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Titolo:
DIURNAL BLOOD-PRESSURE VARIATION AND ALBUMINURIA IN NORMOTENSIVE PATIENTS WITH INSULIN-DEPENDENT DIABETES-MELLITUS
Autore:
VOROS P; LENGYEL Z; NAGY V; NEMETH C; ROSIVALL L; KAMMERER L;
Indirizzi:
SZENT ISTVAN HOSP,DEPT MED 2,NAGYVARAD TER 1 H-1096 BUDAPEST HUNGARY SEMMELWEIS UNIV MED,DEPT MED 2,CTR NEPHROL RES & TRAINING H-1085 BUDAPEST HUNGARY SEMMELWEIS UNIV MED,DEPT PATHOPHYSIOL,CTR NEPHROL RES & TRAINING H-1085 BUDAPEST HUNGARY
Titolo Testata:
Nephrology, dialysis, transplantation
fascicolo: 9, volume: 13, anno: 1998,
pagine: 2257 - 2260
SICI:
0931-0509(1998)13:9<2257:DBVAAI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
IDDM PATIENTS; NON-DIPPERS; MICROALBUMINURIA; NEPHROPATHY; HYPERTENSION;
Keywords:
DIABETES MELLITUS; DIABETIC NEPHROPATHY; MICROALBUMINURIA; BLOOD PRESSURE; CIRCADIAN VARIATION; BLOOD PRESSURE LOAD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
P. Voros et al., "DIURNAL BLOOD-PRESSURE VARIATION AND ALBUMINURIA IN NORMOTENSIVE PATIENTS WITH INSULIN-DEPENDENT DIABETES-MELLITUS", Nephrology, dialysis, transplantation, 13(9), 1998, pp. 2257-2260

Abstract

Background, Abnormalities of the systemic blood pressure are closely associated with the development of diabetic nephropathy. Our aim was to examine the relationship between diurnal blood pressure pattern and albuminuria in insulin-dependent normotensive diabetic patients beforethe development of overt nephropathy. Methods, Urinary albumin excretion rates were determined by radioimmunoassay, and 24-h ambulatory blood pressure monitoring was performed. Means and diurnal index was calculated for systolic, diastolic and mean arterial blood pressure, for day-time, night-time, and the whole day. The results of the normoalbuminuric (n = 39) and microalbuminuric (n = 29) groups are compared, and correlation of the blood pressure parameters with albuminuria is analysed. Results. Twenty-four hours and night-time mean blood pressures were significantly higher, diurnal indices characterizing the night-timeblood pressure drop were smaller in the microalbuminuric group. With multiple regression analysis a significant positive correlation was found between albumin excretion rates and 24-h mean systolic blood pressure and a significant negative correlation between albumin excretion rates and the diurnal index of mean arterial pressure (r(2) = 0.40, P <0.0001). In the normoalbuminuric group 1 (2.6%) patient, in the microalbuminuric group 7 (24.1%) were 'non-dippers'. Conclusion. We conclude that in normotensive insulin-dependent diabetic patients the night-time decrease of blood pressure is smaller if microalbuminuria is present. Higher nocturnal blood pressure load is associated with the increase of albuminuria, even before the onset of overt diabetic nephropathyor hypertension.

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Documento generato il 28/11/20 alle ore 21:48:43