Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
LOW-MOLECULAR-WEIGHT HEPARIN REDUCES TRIGLYCERIDE, VLDL AND CHOLESTEROL HDL LEVELS IN HYPERLIPIDEMIC DIABETIC-PATIENTS ON HEMODIALYSIS/
Autore:
YANG CW; WU TH; HUANG CC;
Indirizzi:
CHANG GUNG MEM HOSP,DIV NEPHROL,199 TUNG HWA N RD TAIPEI 105 TAIWAN
Titolo Testata:
American journal of nephrology
fascicolo: 5, volume: 18, anno: 1998,
pagine: 384 - 390
SICI:
0250-8095(1998)18:5<384:LHRTVA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC-RENAL-FAILURE; DISEASE; LIPIDS; APOLIPOPROTEIN(A); LIPOPROTEINS; PREDICT; PLASMA; RISK;
Keywords:
LOW MOLECULAR WEIGHT HEPARIN; HYPERLIPIDEMIA; HEMODIALYSIS; DIABETES MELLITUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
C.W. Yang et al., "LOW-MOLECULAR-WEIGHT HEPARIN REDUCES TRIGLYCERIDE, VLDL AND CHOLESTEROL HDL LEVELS IN HYPERLIPIDEMIC DIABETIC-PATIENTS ON HEMODIALYSIS/", American journal of nephrology, 18(5), 1998, pp. 384-390

Abstract

Background: Low molecular weight heparin (LMWH) provides a safe and effective alternative for hemodialysis anticoagulation. While unfractionated (UF) heparin has been implicated in hyperlipidemia, the effect of LMWH on the lipid profile in nondiabetic patients is controversial in chronic hemodialysis, The effect of LMWH in diabetic patients, a high risk group of hyperlipidemia, has not been studied. Method: LMWH wastested for its safety and efficacy in 10 nondiabetic Taiwanese patients, To evaluate influence of lipid profile, a crossover study was carried out in 10 type II diabetic patients with poor blood sugar control associated with high triglyceride (430.4 +/- 101.1 mg/dl) and total cholesterol levels (219.2 +/- 12.7 mg/dl) using UF heparin for more than1 year, These patients were subjected to Fraxiparine, an LMWH, for 6 months and then switched back to UF heparin for another 6 months. Lipid profiles were measured every 2 months without prescribing lipid-lowering agents and the blood sugar was maintained at stationary levels, Results: LMWH is safe and effective in Taiwanese patients as a single bolus injection and maintains a 9.4% higher platelet count immediate postdialysis compared to UF heparin, With high HbA1c levels (9.6 +/- 0.6%), mean triglyceride and VLDL levels started to decrease at the 4th month after LMWH treatment and reached a 34% reduction in triglyceride,a 26.2% reduction in VLDL, and a 19% reduction of total cholesterol/HDL ratio at the 6th month, Increments of triglyceride levels were found at the 6th month after a switch back to UF heparin. The levels of total cholesterol, LDL-cholesterol, HDL-cholesterol, apolipoprotein A-1 and B remained unchanged. Conclusion: LMWH may be beneficial to lipid control in hyperlipidemic diabetic patients on hemodialysis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 02:18:37