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Titolo:
TIME-COURSE STUDY OF CELLULAR IMMUNE-RESPONSE AND TESTOSTERONE-METABOLISM IN AN AUTOIMMUNE MODEL FOR CHRONIC PROSTATIC INFLAMMATION
Autore:
DONADIO AC; GAGLIANO H; REMEDI MM; NOWOTNY E; DEPIANTEDEPAOLI M;
Indirizzi:
UNIV NACL CORDOBA,FAC CIENCIAS QUIM,DEPT BIOQUIM CLIN,AGENCIA POSTAL 4,CC 61 RA-5000 CORDOBA ARGENTINA
Titolo Testata:
The Journal of urology
fascicolo: 4, volume: 160, anno: 1998,
pagine: 1546 - 1550
SICI:
0022-5347(1998)160:4<1546:TSOCIA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC ABACTERIAL PROSTATITIS; PERITONEAL-MACROPHAGES; ANTIGENS; 5-ALPHA-REDUCTASE; ACTIVATION; RELEASE; CELLS; EAP;
Keywords:
PROSTATITIS; IMMUNE RESPONSE; TESTOSTERONE METABOLISM; AUTOIMMUNITY; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
A.C. Donadio et al., "TIME-COURSE STUDY OF CELLULAR IMMUNE-RESPONSE AND TESTOSTERONE-METABOLISM IN AN AUTOIMMUNE MODEL FOR CHRONIC PROSTATIC INFLAMMATION", The Journal of urology, 160(4), 1998, pp. 1546-1550

Abstract

Purpose: Little is known of the etiology and pathogenesis of chronic inflammatory prostate diseases of noninfectious origin. In our experimental autoimmune rat model for chronic prostatic inflammation (CPI) weevaluated, in a time-course study, the specific cellular immune response to male accessory glands (MAG) and metabolic activity in the prostate gland. Results obtained in CPI rats were compared with data from rats immunized with kidney homogenate as well as from non-treated rats. Materials and Methods: Specific cellular immune response against MAG antigen(s) was studied by delayed type hypersensitivity (DTH) and lymphocyte proliferation tests. The prostate 5 alpha-reductase activity was studied in prostate homogenates by thin layer chromatography (TLC). Results: DTH values were positive in MAG treated rats sacrificed at days 7 and 28 after first immunization (FI) (p less than or equal to 0.05) in relation to kidney treated and non-treated rats. When we analyzed the proliferative responses to MAG antigen(s), an antigen specific proliferation, as shown by the mean [H-3]thymidine uptake (cpm), was observed in rats sacrificed on days 14 and 28 (p less than or equal to 0.05) after FI. The metabolic studies indicated that the 5a-reductase activity decreased slightly in MAG treated groups at day 14 after FI and diminished significantly at the end of CPI development. Conclusion: These data reveal that the prostatic endocrine cell destruction duringCPI could be a consequence of immune/inflammatory cell mediated processes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 18:31:13