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Titolo:
EXPRESSION OF A DOPAMINE D2 RECEPTOR-ACTIVATED K+ CHANNEL ON IDENTIFIED STRIATOPALLIDAL AND STRIATONIGRAL NEURONS
Autore:
WASZCZAK BL; MARTIN LP; GREIF GJ; FREEDMAN JE;
Indirizzi:
NORTHEASTERN UNIV,DEPT PHARMACEUT SCI,312 MUGAR BLDG,360 HUNTINGTON AVE BOSTON MA 02115
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 19, volume: 95, anno: 1998,
pagine: 11440 - 11444
SICI:
0027-8424(1998)95:19<11440:EOADDR>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT STRIATAL NEURONS; POTASSIUM CHANNELS; GENE-EXPRESSION; MESSENGER-RNAS; D1; BRAIN; LOCALIZATION; MODULATION; PROTEINS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
B.L. Waszczak et al., "EXPRESSION OF A DOPAMINE D2 RECEPTOR-ACTIVATED K+ CHANNEL ON IDENTIFIED STRIATOPALLIDAL AND STRIATONIGRAL NEURONS", Proceedings of the National Academy of Sciences of the United Statesof America, 95(19), 1998, pp. 11440-11444

Abstract

One view of the efferent circuitry of the basal ganglia holds that dopamine D1 and D2 receptors are segregated to striatonigral and striatopallidal neurons, respectively, The present studies investigated whether functional D2-like receptors are, in fact, restricted to striatopallidal neurons. Single, freshly dissociated cells from rat striatum were identified as either striatonigral or striatopallidal projection neurons by fluorescence retrograde labeling. By using cell-attached patch-clamp recordings, neurons of each efferent group were evaluated for the presence of a D2-like receptor-activated 85-pS K+ channel as a measure of receptor function, We now report the presence of this D2 receptor-mediated response on both striatal efferent populations, but we observed an approximately 2-fold higher Likelihood of encountering the channel on pallidal- versus nigral-projecting neurons. The channel's conductance properties appeared identical in both groups of neurons, but there was a significantly greater open probability for channels detected on striatopallidal neurons. These results indicate that functional D2 receptors are not segregated to striatopallidal neurons, but may heexpressed in a higher proportion of, or at a higher density and/or efficiency of coupling on, pallidal- versus nigral-projecting striatal efferents.

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Documento generato il 22/09/20 alle ore 13:52:51