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Titolo:
REGULATORY DYSFUNCTION OF THE INTERLEUKIN-2 RECEPTOR DURING HIV-INFECTION AND THE IMPACT OF TRIPLE COMBINATION THERAPY
Autore:
DAVID D; BANI L; MOREAU JL; TREILHOU MP; NAKARAI T; JOUSSEMET M; RITZ J; DUPONT B; PIALOUX G; THEZE J;
Indirizzi:
INST PASTEUR,DEPT IMMUNOL,UNITE IMMUNOGENET CELLULAIRE F-75724 PARIS FRANCE INST PASTEUR,DEPT IMMUNOL,UNITE IMMUNOGENET CELLULAIRE F-75724 PARIS FRANCE HOP INST PASTEUR PARIS FRANCE DANA FARBER CANC INST,DIV HEMATOL MALIGNANCIES BOSTON MA 02115 CTR TRANSFUS SANGUINE JEAN JULLIARD CLAMART FRANCE
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 19, volume: 95, anno: 1998,
pagine: 11348 - 11353
SICI:
0027-8424(1998)95:19<11348:RDOTIR>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; ACTIVE ANTIRETROVIRAL THERAPY; GAMMA-CHAIN; T-CELLS; EXPRESSION; LYMPHOCYTES; ACTIVATION; CYTOKINE; IL-2; SUBUNIT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
D. David et al., "REGULATORY DYSFUNCTION OF THE INTERLEUKIN-2 RECEPTOR DURING HIV-INFECTION AND THE IMPACT OF TRIPLE COMBINATION THERAPY", Proceedings of the National Academy of Sciences of the United Statesof America, 95(19), 1998, pp. 11348-11353

Abstract

The interleukin-2 (IL-2)/IL-2 receptor (IL-2R) system is the main regulatory determinant of T cell reactivity. Although it is well known that IL-2 secretion is impaired during HN infection, up to now IL-2R expression has not been extensively studied in HIV-infected patients despite the use of IL-2 in clinical therapy trials. We show here that IL-2R expression in HIV patients with high viral load (group 1 in the study) is greatly enhanced on B lymphocytes, CD8 T lymphocytes, and monocytes, but not on CD4 T lymphocytes, compared with noninfected individuals. Paradoxically, this modified IL-2R expression does not lead to increased IL-2 responsiveness, except for B lymphocytes. In patients receiving triple combination therapy (TCT, two reverse transcriptase inhibitors and one protease inhibitor) that has triggered a drastic reduction in plasma viral load and an increase in CD4 counts (group 2 patients), IL-2R expression is significantly lower than in group 1 patients. Moreover, cells involved in cellular immunity and CD4 T lymphocytes have the capacity to respond to IL-2 after TCT. These results allow us to anticipate a beneficial role of IL-2 immunotherapy in combination with TCT.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 21:00:28