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Titolo:
IN-VITRO EVALUATION OF THE RELATIVE THROMBOLYTIC EFFICIENCY OF FORCEDINTRATHROMBIC INJECTIONS - SALINE VERSUS UROKINASE
Autore:
KHILNANI NM; WINCHESTER PA; ZANZONICO P; TROST DW; BINKERT B; SOS TA;
Indirizzi:
CORNELL UNIV,MED CTR,NEW YORK HOSP,DEPT RADIOL,DIV CARDIOVASC & INTERVENT RADIOL,ROOM L-515 NEW YORK NY 10021
Titolo Testata:
Journal of vascular and interventional radiology
fascicolo: 5, volume: 9, anno: 1998,
pagine: 786 - 792
SICI:
1051-0443(1998)9:5<786:IEOTRT>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
PULSE-SPRAY; PHARMACOMECHANICAL THROMBOLYSIS; MODEL; INFUSION;
Keywords:
ARTERIES, THROMBOSIS; THROMBOLYSIS; THROMBOSIS, EXPERIMENTAL; UROKINASE; VEINS, THROMBOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
9
Recensione:
Indirizzi per estratti:
Citazione:
N.M. Khilnani et al., "IN-VITRO EVALUATION OF THE RELATIVE THROMBOLYTIC EFFICIENCY OF FORCEDINTRATHROMBIC INJECTIONS - SALINE VERSUS UROKINASE", Journal of vascular and interventional radiology, 9(5), 1998, pp. 786-792

Abstract

PURPOSE: To compare the rates of thrombolysis produced by forced intrathrombic injections of saline versus urokinase, as well as automated versus manual injections of urokinase, with use of all in vitro model of a vascular occlusion, MATERIALS AND METHODS: The rates of thrombolysis produced by forced intrathrombic injections of saline and urokinase were compared in an in vitro radiometric model utilizing I-125-labeled thrombus, Similar experiments were performed to compare manual and automated injections of urokinase, The dissolution of the thrombus wasquantitatively monitored with use of a scintillation detector. Averaged time activity data for each type of experiment were fit to exponential functions and half times of lysis calculated. The differences in the half times for the experiments being compared were evaluated for significance with use of the Student t test. RESULTS: The half times of lysis produced by forced intrathrombic injections of urokinase were substantially and significantly shorter than those produced by forced saline injections. The half time of lysis produced by automated injections was nod significantly different than that produced by manual injections.CONCLUSIONS: Forced intrathrombic injections of urokinase producefaster and substantially more thrombolysis when compared with similarly administered saline. Also, for forced intrathrombic injections of lytic agents, an automated injector is an equivalent alternative to manual injections.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 19:07:01