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Titolo:
OVERT BEHAVIOR PROBLEMS AND SEROTONERGIC FUNCTION IN MIDDLE CHILDHOODAMONG MALE AND FEMALE OFFSPRING OF ALCOHOLIC FATHERS
Autore:
TWITCHELL GR; HANNA GL; COOK EH; FITZGERALD HE; LITTLE KY; ZUCKER RA;
Indirizzi:
VET AFFAIRS MED CTR,PSYCHOL SERV,116B,11301 WILSHIRE BLVD LOS ANGELESCA 90073 MICHIGAN STATE UNIV,UNIV MICHIGAN LONGITUDINAL STUDY E LANSING MI 48824 UNIV MICHIGAN,ALCOHOL RES CTR ANN ARBOR MI 48109 UNIV MICHIGAN,DEPT PSYCHIAT ANN ARBOR MI 48109 UNIV CHICAGO,DEPT PSYCHIAT,LAB DEV NEUROSCI CHICAGO IL 60637
Titolo Testata:
Alcoholism, clinical and experimental research
fascicolo: 6, volume: 22, anno: 1998,
pagine: 1340 - 1348
SICI:
0145-6008(1998)22:6<1340:OBPASF>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
FLUID 5-HYDROXYINDOLEACETIC ACID; DEFICIT HYPERACTIVITY DISORDER; WHOLE-BLOOD SEROTONIN; PLATELET SEROTONIN; MONOAMINE METABOLITES; IMPULSIVE AGGRESSION; IMIPRAMINE BINDING; CONDUCT DISORDER; ETHANOL INTAKE; EARLY-ONSET;
Keywords:
WHOLE BLOOD SEROTONIN (5-HT); BEHAVIORAL UNDERCONTROL; CHILDREN OF ALCOHOLICS; ALCOHOLIC SUBTYPES; BIOLOGICAL MARKERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
64
Recensione:
Indirizzi per estratti:
Citazione:
G.R. Twitchell et al., "OVERT BEHAVIOR PROBLEMS AND SEROTONERGIC FUNCTION IN MIDDLE CHILDHOODAMONG MALE AND FEMALE OFFSPRING OF ALCOHOLIC FATHERS", Alcoholism, clinical and experimental research, 22(6), 1998, pp. 1340-1348

Abstract

A large body of literature indicates that the serotonergic system is involved in behavioral regulation, as evidenced by the inverse relationship between impulsive aggression and serotonergic function found in adult alcoholics and nonalcoholics. However, studies of this relationship among child and adolescent offspring of alcoholics (COAs) have notpreviously been done. This study examines the potentially parallel relationship between behavioral dysregulation and low serotonergic function in young COAs. The relationship is of potential interest as a phenotypic marker of biological vulnerability to aggressiveness, which itself has been hypothesized to be a risk factor for later antisocial alcoholism. The present work is part of an ongoing prospective study of the development of risk for alcohol abuse/dependence and other problematic outcomes in a sample of families subtyped by the fathers' alcoholism classification. We examined the relationship between overt behaviorproblems in middle childhood (mean age = 10.5 +/- 1.7 years) and whole blood serotonin (5-HT) in a subsample of the offspring (N = 32 boys and 12 girls). Using a Child Behavior Checklist (CBCL) index of behavioral under-control, we obtained results indicating that high total behavior problem (TBP) children had lower levels of whole blood 5-HT thandid low-TBP children (p < 0.01). These results support the hypothesisthat there is an inverse relationship between whole blood serotonin levels and behavior problems in young male and female CCAs. A father's alcoholism status was not significantly related to his child's 5-HT level, i.e., the child's phenotypic expression of behavioral dysregulation was more reliably connected to serotonergic function than was paternal alcoholism.

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Documento generato il 23/01/20 alle ore 03:59:54