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Titolo:
MODULATION OF VOLITIONAL ETHANOL INTAKE IN THE RAT BY CENTRAL DELTA-OPIOID RECEPTORS
Autore:
FRANCK J; LINDHOLM S; RAASCHOU P;
Indirizzi:
KAROLINSKA INST,DEPT PHYSIOL & PHARMACOL S-17177 STOCKHOLM SWEDEN KAROLINSKA INST,DEPT CLIN NEUROSCI S-17177 STOCKHOLM SWEDEN
Titolo Testata:
Alcoholism, clinical and experimental research
fascicolo: 6, volume: 22, anno: 1998,
pagine: 1185 - 1189
SICI:
0145-6008(1998)22:6<1185:MOVEII>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALCOHOL-PREFERRING AA; FREELY MOVING RATS; AVOIDING ANA RATS; OPIATE RECEPTORS; ENDOGENOUS OPIOIDS; NUCLEUS-ACCUMBENS; DOPAMINE RELEASE; CONSUMPTION; NALTREXONE; PREFERENCE;
Keywords:
ETHANOL INTAKE; FREE-CHOICE; NALTREXONE; NALTRINDOLE; OPIOID RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
J. Franck et al., "MODULATION OF VOLITIONAL ETHANOL INTAKE IN THE RAT BY CENTRAL DELTA-OPIOID RECEPTORS", Alcoholism, clinical and experimental research, 22(6), 1998, pp. 1185-1189

Abstract

The acute effect of opioid antagonists on volitional ethanol intake was studied in unselected Sprague-Dawley rats using a two-bottle, free-choice model. The total daily intake of ethanol during saline treatment was 1.79 +/- 0.4 g/kg/day (n = 136). The rats were deprived of fluids for the last 4 hr of the light period. Saline or drug was given intraperitoneally 20 to 30 min before the onset of dark, and the ethanol and water intakes were measured during the following hour. The ethanol intake during this hour was 0.75 +/- 0.06 g/kg (n = 136). Naltrexone significantly reduced ethanol intake. There was also a significant reduction in ethanol intake following administration of ICI-174,864. Naloxonazine and naloxone methiodide lacked effect. None of the treatments had any effect on the water or food intake. The results suggest that central delta-opioid receptors modulate volitional ethanol intake in the rat.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 07:44:37