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Titolo:
ISOLATION OF AN ACTIVE PEPTIDE FRAGMENT FROM HUMAN SERUM-ALBUMIN AND ITS SYNERGISM WITH ALPHA-TOCOPHEROL
Autore:
HATATE H;
Indirizzi:
NATL FISHERIES UNIV,DEPT FOOD SCI & TECHNOL SHIMONOSEKI YAMAGUCHI 75965 JAPAN
Titolo Testata:
Journal of the American Oil Chemists' Society
fascicolo: 9, volume: 75, anno: 1998,
pagine: 1135 - 1139
SICI:
0003-021X(1998)75:9<1135:IOAAPF>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIOXIDANT ACTIVITY; VITAMIN-E; INHIBITION; CARNOSINE; OXIDATION;
Keywords:
ANTIOXIDANT; HUMAN SERUM ALBUMIN; PEPTIDE SYNERGIST; SYNERGISTIC EFFECT; TOCOPHEROL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
H. Hatate, "ISOLATION OF AN ACTIVE PEPTIDE FRAGMENT FROM HUMAN SERUM-ALBUMIN AND ITS SYNERGISM WITH ALPHA-TOCOPHEROL", Journal of the American Oil Chemists' Society, 75(9), 1998, pp. 1135-1139

Abstract

An active peptide was isolated from hydrolysates of human serum albumin. This peptide was initially isolated by gel permeation chromatography and subsequent reversed phase high-performance liquid chromatography. This active peptide, composed of 10 amino acid residues, was further hydrolyzed with a lysyl endopeptidase to give two peptide fragments. Only one fragment, identified as the tetrapeptide Leu-Gln-His-Lys, was found to have activity comparable to the original peptide and corresponded to the amino acid residues 103-106 of human serum albumin. Among these four amino acid residues, the His-Lys sequence seemed to be important in the occurrence of potent activity by comparison of the structural similarity with another active tetrapeptide, Asp-Thr-His-Lys, which had been previously isolated from bovine serum albumin hydrolysates. In addition, the active fragment showed potent synergism by preventing consumption of alpha-tocopherol during the autoxidation of linoleic acid.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 00:50:47