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Titolo:
CONTRIBUTION OF NICOTINIC RECEPTORS TO THE FUNCTION OF SYNAPSES IN THE CENTRAL-NERVOUS-SYSTEM - THE ACTION OF CHOLINE AS A SELECTIVE AGONIST OF ALPHA-7 RECEPTORS
Autore:
ALBUQUERQUE EX; PEREIRA EFR; BRAGA MFM; ALKONDON M;
Indirizzi:
UNIV MARYLAND,SCH MED,DEPT PHARMACOL & EXPT THERAPEUT BALTIMORE MD 21201 UNIV FED RIO DE JANEIRO,CTR HLTH SCI,INST BIOMED SCI,DEPT BASIC & CLIN PHARMACOL BR-21941 RIO JANEIRO BRAZIL
Titolo Testata:
JOURNAL OF PHYSIOLOGY-PARIS
fascicolo: 3-4, volume: 92, anno: 1998,
pagine: 309 - 316
SICI:
0928-4257(1998)92:3-4<309:CONRTT>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACETYLCHOLINE-RECEPTORS; SYNAPTIC TRANSMISSION; PYRAMIDAL CELLS; INTERNEURONS; HIPPOCAMPUS; NEURONS;
Keywords:
CHOLINE; NICOTINIC RECEPTORS; SLICES; HIPPOCAMPUS; GABA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
E.X. Albuquerque et al., "CONTRIBUTION OF NICOTINIC RECEPTORS TO THE FUNCTION OF SYNAPSES IN THE CENTRAL-NERVOUS-SYSTEM - THE ACTION OF CHOLINE AS A SELECTIVE AGONIST OF ALPHA-7 RECEPTORS", J PHYSL-PAR, 92(3-4), 1998, pp. 309-316

Abstract

The alpha 7-nicotinic receptor (nAChR)-selective agonist choline and nAChR-subtype-selective antagonists led to the discovery that activation of both alpha 7 and alpha 4 beta 2 nAChRs located in CA1 interneurons in slices taken from the rat hippocampus facilitates the tetrodotoxin (TTX)-sensitive release of gamma-aminobutyric acid (GABA). Experiments carried out in cultured hippocampal neurons not only confirmed that preterminal alpha 7 and alpha 4 beta 2 nAChRs modulate the TTX-sensitive release of GABA, bur also demonstrated that evoked release of GABA is reduced by rapid exposure of the neurons to acetylcholine (ACh, 10 mu M-1 mM) in the presence of the muscarinic receptor antagonist atropine (1 mu M). This effect of ACh, which is fully reversible and concentration-dependent, is partially blocked by superfusion of the cultured neurons with external solution containing either the alpha 7-nAChR-selective antagonist methyllycaconitine (MLA, 1 nM) or the alpha 4 beta 2-nAChR-selective antagonist dihydro-beta-erythroidine (DH beta E, 100 nM). A complete blockade of ACh-induced reduction of evoked releaseof GABA was achieved only when the neurons were perfused with external solution containing both MLA and DH beta E, suggesting that activation of both alpha 7 and alpha 4 beta 2 nAChRs modulates the evoked release of GABA from hippocampal neurons. Such mechanisms may account for the apparent involvement of nAChRs in the psychological effects of tobacco smoking, in brain disorders (e.g., schizophrenia and epilepsy), and in physiological processes, including cognition and nociception. ((C)Elsevier, Paris).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 13:01:01