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Titolo:
MOLECULAR MECHANISMS FOR THE REGULATION OF THE EXPRESSION AND FUNCTION OF MUSCARINIC ACETYLCHOLINE-RECEPTORS
Autore:
HAMILTON SE; SCHLADOR ML; MCKINNON LA; CHMELAR RS; NATHANSON NM;
Indirizzi:
UNIV WASHINGTON,DEPT PHARMACOL,BOX 357750 SEATTLE WA 98195 UNIV WASHINGTON,DEPT PHARMACOL SEATTLE WA 98195
Titolo Testata:
JOURNAL OF PHYSIOLOGY-PARIS
fascicolo: 3-4, volume: 92, anno: 1998,
pagine: 275 - 278
SICI:
0928-4257(1998)92:3-4<275:MMFTRO>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIATED GENE-TRANSCRIPTION; TISSUE-SPECIFIC REGULATION; BETA-ARRESTIN; DESENSITIZATION; ACTIVATION; PROTEINS; M1;
Keywords:
MUSCARINIC RECEPTOR; KNOCKOUT MOUSE; SEIZURES; DESENSITIZATION; RETINA; POTASSIUM CHANNEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
S.E. Hamilton et al., "MOLECULAR MECHANISMS FOR THE REGULATION OF THE EXPRESSION AND FUNCTION OF MUSCARINIC ACETYLCHOLINE-RECEPTORS", J PHYSL-PAR, 92(3-4), 1998, pp. 275-278

Abstract

The regulation of muscarinic acetylcholine receptor expression and function was investigated in cultured cells and in knockout mice. Muscarinic agonist exposure causes m2 receptor desensitization and sequestration and decreases the expression of cardiac potassium channels. The expression of m2 receptors in chick retina is regulated by a developmentally regulated secreted factor. Mice lacking the mi receptor exhibit a loss of muscarinic regulation of M-current potassium channel activity and pilocarpine-induced seizures. ((C)Elsevier, Paris).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 07:33:16