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Titolo:
INTRAARTERIAL VS INTRAVENOUS ADMINISTRATION OF ANTIVENIN FOR THE TREATMENT OF CROTALIDAE ATROX ENVENOMATION - A PILOT-STUDY
Autore:
BANIA TC; BERNSTEIN SL; BARON BJ; RABINOWITZ D;
Indirizzi:
COLUMBIA UNIV,ST LUKES ROOSEVELT HOSP CTR,DEPT EMERGENCY MED,COLL PHYS & SURG,1000 10TH AVE NEW YORK NY 10019 SUNY HLTH SCI CTR,HLTH SCI CTR,DEPT EMERGENCY MED BROOKLYN NY 11203 COLUMBIA UNIV,DEPT STAT NEW YORK NY 00000
Titolo Testata:
Academic emergency medicine
fascicolo: 9, volume: 5, anno: 1998,
pagine: 894 - 898
SICI:
1069-6563(1998)5:9<894:IVIAOA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYDROFLUORIC-ACID BURNS; INFUSION;
Keywords:
SNAKE ENVENOMATION; INTRAARTERIAL; ANTIVENIN; CROTALIDAE ATROX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
T.C. Bania et al., "INTRAARTERIAL VS INTRAVENOUS ADMINISTRATION OF ANTIVENIN FOR THE TREATMENT OF CROTALIDAE ATROX ENVENOMATION - A PILOT-STUDY", Academic emergency medicine, 5(9), 1998, pp. 894-898

Abstract

Objective: Standard therapy for significant snake envenomation includes antivenin. TV administration is currently the only recommended route. Intraarterial (IA) administration has potential advantages over IV that could improve outcome. To study this, the authors compared IV andIA antivenin administrations for the treatment of experimental snake envenomations. Methods: 14 adult female swine were anesthetized and prepared with femoral artery and ear vein catheters, and baseline hoof, forearm, and thigh circumference and volume displacement measurements were taken. Crotalidae atrox venom was injected into the subcutaneous tissue of the hoof. The doses of venom were 4.75, 9.50, 19.00, 37.90, 47.30, 56.90, and 66.40 mg. Immediately following injection of venom, polyvalent antivenin (Crotalidae) (0.285 mg/10 mt saline) was infused over 30 minutes into the femoral artery (IA group) or ear vein (IV group). As a control, 10 mt of saline was infused into the ear vein (IA group) or femoral artery (IV group). Measurements were recorded up to 48 hours. Linear mixed-effect regression models were used for each measurement and to compare the IA and IV groups. Results: Venom dose and time after administrations were associated with increased circumferences and increased volumes (p < 0.05). IV administration was associated with larger hoof (1.26 cm) and forearm (0.42 cm) sizes and volume displacement (21.71 mt) when compared with IA administration ( p < 0.05). Conclusion: IA antivenin results in a modest but significant decrease in tissue edema when compared with IV.

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Documento generato il 04/12/20 alle ore 22:12:23