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Titolo:
BASAL COCHLEAR LESIONS RESULT IN INCREASED AMPLITUDE OF OTOACOUSTIC EMISSIONS
Autore:
KAKIGI A; HIRAKAWA H; HAREL N; MOUNT RJ; HARRISON RV;
Indirizzi:
HOSP SICK CHILDREN,DEPT OTOLARYNGOL,555 UNIV AVE TORONTO ON M5G 1X8 CANADA HOSP SICK CHILDREN,DEPT OTOLARYNGOL TORONTO ON M5G 1X8 CANADA UNIV TORONTO,DEPT OTOLARYNGOL,AUDITORY SCI LAB TORONTO ON CANADA
Titolo Testata:
Audiology & neuro-otology
fascicolo: 6, volume: 3, anno: 1998,
pagine: 361 - 372
SICI:
1420-3030(1998)3:6<361:BCLRII>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACOUSTIC DISTORTION PRODUCTS; OTOTOXICITY; NEPHROTOXICITY; ANTIBIOTICS; AMIKACIN; BLOOD;
Keywords:
AMINOGLYCOSIDE; AMIKACIN; OTOTOXICITY; OTOACOUSTIC EMISSION; MONITORING; SCANNING ELECTRON MICROSCOPY; COCHLEOGRAM; AUDITORY BRAIN-STEM EVOKED RESPONSES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
A. Kakigi et al., "BASAL COCHLEAR LESIONS RESULT IN INCREASED AMPLITUDE OF OTOACOUSTIC EMISSIONS", Audiology & neuro-otology, 3(6), 1998, pp. 361-372

Abstract

We have measured the changes in transient otoacoustic emissions (TEOAEs) and distortion product otoacoustic emissions (DPOAEs) during and after ototoxic amikacin treatment in an animal (chinchilla) model. TEOAE and DPOAE were recorded from 6 adult chinchillas over a 6-week time course starting just before a 5-day or 7-day treatment period with amikacin sulphate (400 mg/kg/day, i.m.). After final recordings, cochlearmorphology was assessed by scanning electron microscopy. Generally, both DPOAE and TEOAE amplitudes change during and after treatment in a systematic fashion. High-frequency components change first, followed by lower-frequency components. We note that there is often a long latency to the onset of changes in otoacoustic emissions (OAE), and that these changes can continue for weeks after treatment. Most importantly we report that when the basal region of the cochlea is damaged in the frequency region above the OAE recording bandwidth (0.6-6 kHz for TEOAE; 1-6.7 kHz for DPOAE), we often find an increase in OAE amplitudes. More specifically, we note that as a cochlear lesion progresses apically, there is often a transient increase in a frequency-specific OAE before it reduces or is lost. Our results suggest that the increase in OAE amplitudes precedes the expression of detectable cochlear pathology.

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Documento generato il 25/11/20 alle ore 04:19:50