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Titolo:
INNATE RESISTANCE TO INFECTION BY INTRACELLULAR BACTERIAL PATHOGENS DIFFERS IN MICE SELECTED FOR MAXIMAL OR MINIMAL ACUTE INFLAMMATORY RESPONSE
Autore:
ARAUJO LMM; RIBEIRO OG; SIQUEIRA M; DEFRANCO M; STAROBINAS N; MASSA S; CABRERA WHK; MOUTON D; SEMAN M; IBANEZ OM;
Indirizzi:
INST BUTANTAN,LAB IMUNOGENET,AV VITAL BRAZIL 1500 BR-05503900 SAO PAULO SP BRAZIL INST BUTANTAN,LAB IMUNOGENET BR-05503900 SAO PAULO SP BRAZIL INST CURIE,U255 INSERM PARIS FRANCE UNIV PARIS 07,LAB IMMUNODIFFERENCIAT PARIS FRANCE
Titolo Testata:
European Journal of Immunology
fascicolo: 9, volume: 28, anno: 1998,
pagine: 2913 - 2920
SICI:
0014-2980(1998)28:9<2913:IRTIBI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; SALMONELLA-TYPHIMURIUM INFECTION; NATURAL-KILLER-CELLS; LISTERIA-MONOCYTOGENES; DISEASE RESISTANCE; GAMMA INTERFERON; GENETIC-CONTROL; SEPTIC SHOCK; FACTOR-ALPHA; PARASITES;
Keywords:
INFLAMMATION; SALMONELLA TYPHIMURIUM; NRAMP-1; IMMUNE RESPONSE; LISTERIA MONOCYTOGENES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
L.M.M. Araujo et al., "INNATE RESISTANCE TO INFECTION BY INTRACELLULAR BACTERIAL PATHOGENS DIFFERS IN MICE SELECTED FOR MAXIMAL OR MINIMAL ACUTE INFLAMMATORY RESPONSE", European Journal of Immunology, 28(9), 1998, pp. 2913-2920

Abstract

The intensity of nonspecific immune reaction and the host resistance to facultative intracellular pathogens are found to be associated in lines of mice selected for maximal (AIRmax) or minimal (AIRmin) acute inflammatory reactivity. AIRmax are more resistant than AIRmin mice to Salmonella typhimurium and Listeria monocytogenes infection, the differences between lines in LD,, being >1000 and 100 times, respectively. This difference was shown to be related to the initial bacterial containment at the infectious focus, and to the control of bacterial multiplication in the spleen during the 1 st week after s.c. inoculation of the bacteria. Specific immune responses were not deeply affected by the selective process: antibody production and delayed-type hypersensitivity were both of similar intensity in AIRmax and AIRmin mice. The differential susceptibility to infection seems independent of the Nramp-1locus polymorphism; therefore, these two lines represent a powerful model for investigating the role of other genetic loci regulating the nonspecific immunity effecters in the course of infectious diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 05:34:59