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Titolo:
GOOD GROWTH DESPITE VERY-LOW LEVELS OF INSULIN-LIKE GROWTH-FACTORS
Autore:
DOTSCH J; SIEBLER T; BLUM WF; RASCHER W; KIESS W;
Indirizzi:
DEPT PAEDIAT,FEULGENSTR 12 D-35385 GIESSEN GERMANY DEPT PAEDIAT D-35385 GIESSEN GERMANY
Titolo Testata:
European journal of pediatrics
fascicolo: 9, volume: 157, anno: 1998,
pagine: 712 - 714
SICI:
0340-6199(1998)157:9<712:GGDVLO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORMONE DEFICIENCY; SOMATOMEDIN-C; FACTOR-I; IGF-I; SECRETION; DIAGNOSIS;
Keywords:
INSULIN-LIKE GROWTH FACTOR; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3 GROWTH HORMONE DEFICIENCY; MESENTERIC CYST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
9
Recensione:
Indirizzi per estratti:
Citazione:
J. Dotsch et al., "GOOD GROWTH DESPITE VERY-LOW LEVELS OF INSULIN-LIKE GROWTH-FACTORS", European journal of pediatrics, 157(9), 1998, pp. 712-714

Abstract

A 12.5-year-old girl presented with short stature. Insulin-like growth factor 1(IGF-I) and insulin- like growth factor binding protein (IGFBP-3) were below the 0.1 percentile. Growth hormone provocation tests disclosed normal responses to L-arginine and insulin-induced hypoglycaemia. A huge benign mesenteric cyst: was discovered by abdominal ultrasound and completely removed. Subsequently, the girl showed a marked catch-up growth; however, IGF-I and IGFBP-3 remained below the 0.1 percentile. Conclusion These observations imply that growth may take placeeven with very low levels of insulin-like growth factors. The interpretation of low IGF-I and IGFBP-3 levels in short children still requires good clinical judgement and basic knowledge of their biological action.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 21:27:33