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Titolo:
AN EVALUATION OF MEASURES OF SYNONYMOUS CODON USAGE BIAS
Autore:
COMERON JM; AGUADE M;
Indirizzi:
UNIV BARCELONA,FAC BIOL,DEPT GENET,AV DIAGONAL 645 BARCELONA SPAIN
Titolo Testata:
Journal of molecular evolution
fascicolo: 3, volume: 47, anno: 1998,
pagine: 268 - 274
SICI:
0022-2844(1998)47:3<268:AEOMOS>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPRESSED GENES; SELECTION; YEAST;
Keywords:
SYNONYMOUS CODON USAGE BIAS; ESTIMATION METHODS; EFFECTIVE NUMBER OF CODONS; CODON BIAS INDEX; CODON ADAPTATION INDEX; SCALED CHI(2); INTRINSIC CODON BIAS INDEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
J.M. Comeron e M. Aguade, "AN EVALUATION OF MEASURES OF SYNONYMOUS CODON USAGE BIAS", Journal of molecular evolution, 47(3), 1998, pp. 268-274

Abstract

Synonymous codons are not generally used at equal frequencies, and this trend is observed for most genes and organisms. Several methods have been proposed and used to estimate the degree of the nonrandom use of the different synonymous codons. The estimates obtained by these methods, however, show different levels of both precision and dispersion when coding regions of a finite number of codons are under analysis. Hen, we present a study, based on computer simulation, of how the different methods proposed to evaluate the nonrandom use of synonymous codons are affected by the length of the coding region analyzed. The results show that some of these methods are heavily influenced by the number of codons and that the comparison of codon usage bias between codingregions of different lengths shows a methodological bias under different conditions of nonrandom use of synonymous codons. The study of thedispersion of the estimates obtained by the different methods gives, on the other hand, an indication of the methods to be applied to compare values of codon usage bias among coding regions of equivalent length.

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Documento generato il 04/12/20 alle ore 22:31:10