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Titolo:
ESTABLISHMENT AND CHARACTERIZATION OF A NEW CELL-LINE DERIVED FROM FELINE MAMMARY-TUMOR
Autore:
MULEYA JS; NAKAICHI M; SUGAHARA J; TAURA Y; MURATA T; NAKAMA S;
Indirizzi:
YAMAGUCHI UNIV,DEPT VET SURG,YOSHIDA 1677-1 YAMAGUCHI 7538510 JAPAN YAMAGUCHI UNIV,VET HOSP,DEPT VET SURG YAMAGUCHI 7538515 JAPAN YAMAGUCHI UNIV,SCH MED,DEPT VET SURG,LAB ANIM YAMAGUCHI 7558505 JAPAN
Titolo Testata:
Journal of veterinary medical science
fascicolo: 8, volume: 60, anno: 1998,
pagine: 931 - 935
SICI:
0916-7250(1998)60:8<931:EACOAN>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-BREAST-CANCER; PROGNOSTIC FACTORS; NUDE-MICE; CARCINOMAS; MODEL; SENESCENCE; RECEPTORS; GROWTH; CANINE; CATS;
Keywords:
ADENOCARCINOMA; CELL LINE; FELINE; MAMMARY GLAND; TELOMERASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
J.S. Muleya et al., "ESTABLISHMENT AND CHARACTERIZATION OF A NEW CELL-LINE DERIVED FROM FELINE MAMMARY-TUMOR", Journal of veterinary medical science, 60(8), 1998, pp. 931-935

Abstract

A new cell line designated FRM was established from pleural effusion of a 13-year-old female cat with mammary adenocarcinoma. The cell lineexhibited irregular round and polygonal shaped epithelial cells and demonstrated cell growth in a monolayer fashion with a doubling time of22.4 hr. It possessed a modal chromosome number of 79. The immortality of this cell line was demonstrated using the TRAP assay which revealed a high telomeric activity of these cells. Scatchard analysis revealed quite low levels of estrogen receptors in both tumor mass produced in nude mice and FRM cells. Subcutaneous transplantation of the cells produced localized palpable masses in athymic nude mice within two weeks. This cell line may provide a good model for in vivo and in vitro studies on feline mammary tumors.

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Documento generato il 30/11/20 alle ore 06:55:24