Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
STRESS-INDUCED EXPRESSION OF TRANSCRIPTIONAL REPRESSOR ICER IN THE ADRENAL-GLAND
Autore:
DELLAFAZIA MA; SERVILLO G; FOULKES NS; SASSONECORSI P;
Indirizzi:
UNIV LOUIS PASTEUR STRASBOURG 1,INST GENET & BIOL MOL & CELLULAIRE,CNRS,INSERM,BP 163 F-67404 ILLKIRCH GRAFFENS FRANCE UNIV LOUIS PASTEUR STRASBOURG 1,INST GENET & BIOL MOL & CELLULAIRE,CNRS,INSERM F-67404 ILLKIRCH GRAFFENS FRANCE
Titolo Testata:
FEBS letters
fascicolo: 1-2, volume: 434, anno: 1998,
pagine: 33 - 36
SICI:
0014-5793(1998)434:1-2<33:SEOTRI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM DESENSITIZATION; DEPENDENT PROTEIN-KINASE; CYCLIC-AMP; CREM GENE; CELL-CYCLE; INDUCTION; RECEPTOR; ADENOSINE-3',5'-MONOPHOSPHATE; CORTICOSTERONE; INDUCIBILITY;
Keywords:
INDUCIBLE CAMP EARLY REPRESSOR; CAMP-RESPONSIVE ELEMENT MODULATOR; ADRENOCORTICOTROPIN HORMONE; ADRENAL GLAND; SURGERY; STRESS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
M.A. Dellafazia et al., "STRESS-INDUCED EXPRESSION OF TRANSCRIPTIONAL REPRESSOR ICER IN THE ADRENAL-GLAND", FEBS letters, 434(1-2), 1998, pp. 33-36

Abstract

Second messenger cyclic AMP plays a central role in signalling withinthe hypothalamo-pituitary-adrenal (HPA) axis. Changes in gene expression are central to long-term adaptations made in response to stress inthe adrenal gland. Here we demonstrate that expression of the cAMP inducible transcriptional repressor, ICER (Inducible cAMP Early Repressor), is rapidly and powerfully induced in response to surgical stress in the rat adrenal gland. Hypophysectomisation blocks stress-induced ICER expression. Finally we demonstrate that injection of the pituitary hormone ACTH (Adrenocorticotropin Hormone) induces robust ICER expression in the adrenal cortex. Thus, induction of the transcriptional repressor ICER is coupled to the HPA axis response to stress. (C) 1998 Federation of European Biochemical Societies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 00:49:59