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Titolo:
DIMINISHED ADHERENCE AND OR INGESTION OF VIRULENT MYCOBACTERIUM-TUBERCULOSIS BY MONOCYTE-DERIVED MACROPHAGES FROM PATIENTS WITH TUBERCULOSIS/
Autore:
ZABALETA J; ARIAS M; MAYA JR; GARCIA LF;
Indirizzi:
UNIV ANTIOQUIA,FAC MED,LAB CENT INVEST MEDELLIN AA1226 COLOMBIA UNIV ANTIOQUIA,FAC MED,LAB CENT INVEST MEDELLIN AA1226 COLOMBIA HOSP MARIA,PROGRAMA CONTROL TB MEDELLIN COLOMBIA
Titolo Testata:
Clinical and diagnostic laboratory immunology
fascicolo: 5, volume: 5, anno: 1998,
pagine: 690 - 694
SICI:
1071-412X(1998)5:5<690:DAAOIO>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPLEMENT RECEPTORS; NONOPSONIC BINDING; MURINE MACROPHAGES; PHAGOCYTOSIS; LIPOARABINOMANNAN; CELLS; IDENTIFICATION; ENHANCEMENT; ACTIVATION; GROWTH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
J. Zabaleta et al., "DIMINISHED ADHERENCE AND OR INGESTION OF VIRULENT MYCOBACTERIUM-TUBERCULOSIS BY MONOCYTE-DERIVED MACROPHAGES FROM PATIENTS WITH TUBERCULOSIS/", Clinical and diagnostic laboratory immunology, 5(5), 1998, pp. 690-694

Abstract

The interaction between the macrophage and Mycobacterium tuberculosisis mediated by a variety of macrophage membrane-associated proteins. Complement receptors have been implicated in the adherence of M. tuberculosis to macrophages, In the present work, the adherence and/or ingestion of M. tuberculosis H37Rv to human monocyte-derived macrophages (MDM) from patients with tuberculosis (TB) and healthy controls was measured by microscopical examination, [H-3]uracil incorporation, and CFU, The adherence and/or ingestion was enhanced by fresh serum and inhibited by heat inactivation, EDTA treatment, and anti-CR1 and anti-CR3 antibodies. Comparison of MDM from TB patients and healthy controls showed that the former exhibited a significantly decreased capacity to adhere and/or ingest M. tuberculosis, as determined by the number of CFUand H-3 incorporation. The expression of CR1 (CD35) and CR3 (CD11b/CD18) on MDM from TB patients and healthy controls, as determined by flow cytometry, did not show significant differences. These results suggest that the lower ingestion of M. tuberculosis by MDM from TB patientsis not due to defects in complement receptors, and therefore, there might be other molecules involved in the adherence and/or ingestion process that render MDM from TB patients ingest less mycobacteria than those from healthy controls.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 04:41:40