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Titolo:
LACUNAR INFARCTS DEFINED BY MAGNETIC-RESONANCE-IMAGING OF 3660 ELDERLY PEOPLE - THE CARDIOVASCULAR HEALTH STUDY
Autore:
LONGSTRETH WT; BERNICK C; MANOLIO TA; BRYAN N; JUNGREIS CA; PRICE TR;
Indirizzi:
UNIV WASHINGTON,HARBORVIEW MED CTR,DEPT NEUROL,BOX 359775,325 9TH AVESEATTLE WA 98104 UNIV WASHINGTON,DEPT EPIDEMIOL SEATTLE WA 98104 UNIV CALIF DAVIS,DEPT NEUROL DAVIS CA 00000 NHLBI,DIV EPIDEMIOL & CLIN APPLICAT BETHESDA MD 20892 JOHNS HOPKINS UNIV,SCH MED,DEPT RADIOL,NEURORADIOL DIV BALTIMORE MD 21205 UNIV PITTSBURGH,MED CTR,DEPT RADIOL PITTSBURGH PA 00000 UNIV PITTSBURGH,MED CTR,DEPT NEUROL SURG PITTSBURGH PA 00000 UNIV MARYLAND,DEPT NEUROL BALTIMORE MD 21201
Titolo Testata:
Archives of neurology
fascicolo: 9, volume: 55, anno: 1998,
pagine: 1217 - 1225
SICI:
0003-9942(1998)55:9<1217:LIDBMO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
SILENT CEREBRAL INFARCTION; RISK-FACTORS; DIABETES-MELLITUS; BRAIN INFARCTION; CAROTID STENOSIS; OLDER ADULTS; STROKE; DISEASE; ABNORMALITIES; HYPOTHESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
W.T. Longstreth et al., "LACUNAR INFARCTS DEFINED BY MAGNETIC-RESONANCE-IMAGING OF 3660 ELDERLY PEOPLE - THE CARDIOVASCULAR HEALTH STUDY", Archives of neurology, 55(9), 1998, pp. 1217-1225

Abstract

Objective: To identify risk factors for and functional consequences of lacunar infarct in elderly people. Methods: The Cardiovascular Health Study (CHS) is a longitudinal study of people 65 years or older, in which 3660 participants underwent cranial magnetic resonance imaging (MRI). Neuroradiologists read scans in a standard fashion without any clinical information. lacunes were defined as subcortical areas consistent with infarcts measuring 3 to 20 mm. In cross-sectional analyses, clinical correlates were contrasted among groups defined by MRI findings. Results: Of the 3660 subjects who underwent MRI, 2529 (69%) were free of infarcts of any kind and 841 (23%) had 1 or more lacunes withoutother types present, totaling 1270 lacunes. For most of these 841 subjects, their lacunes were single (66%) and silent (89%), namely without a history of transient ischemic attack or stroke. In multivariate analyses, factors independently associated with lacunes were increased age, diastolic blood pressure, creatinine, and pack-years of smoking (listed in descending order of strength of association; for all, P<.005), as well as maximum internal carotid artery stenosis of more than 50%(odds ratio [OR], 1.81; P<.005), male sex (OR, 0.74; P<.005), and history of diabetes at entrance into the study (OR, 1.33; P<.05). Models for subgroups of single, multiple, silent, and symptomatic lacunes differed only minimally. Those with silent lacunes had more cognitive, upper extremity, and lower extremity dysfunction not recognized as stroke than those whose MRIs were free of infarcts. Conclusions: In this group of older adults, lacunes defined by MRI are common and associated with factors that likely promote or reflect small-vessel disease. Silent lacunes are also associated with neurologic dysfunction.

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Documento generato il 05/12/20 alle ore 16:10:02