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Titolo:
ASSOCIATION OF N-ACETYLLACTOSAMINE WITH TUMOR PROGRESSION IN HUMAN BREAST-CANCER - A STUDY USING A 16 KDA CHICK-EMBRYO LECTIN
Autore:
HENOU C; DIDIER E; DELATOUR M; KWIATKOWSKI F; COMMUNAL Y; BESSE G; BIGNON YJ;
Indirizzi:
UNIV CLERMONT FERRAND,IMMUNOL LAB,24 AVE LANDAIS F-63177 CLERMONT FERRA FRANCE INSERM,CRI 9502,ANAT PATHOL LAB,CTR JEAN PERRIN F-63011 CLERMONT FERRA 01 FRANCE INSERM,CRI 9502,STAT LAB,CTR JEAN PERRIN F-63011 CLERMONT FERRA 01 FRANCE INSERM,CRI 9502,IMMUNOL LAB,CTR JEAN PERRIN F-63011 CLERMONT FERRA 01FRANCE INSERM,CRI 9502,LAB RADIOANAL & RADIOPHARM,CTR JEAN PERRIN F-63011 CLERMONT FERRA 01 FRANCE INSERM,CRI 9502,ONCOL MOL LAB,CTR JEAN PERRIN F-63011 CLERMONT FERRA 01 FRANCE
Titolo Testata:
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
fascicolo: 4, volume: 1, anno: 1998,
pagine: 771 - 775
SICI:
1107-3756(1998)1:4<771:AONWTP>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
BINDING PROTEIN GALECTIN-3; PEANUT AGGLUTININ BINDING; LYMPH-NODE METASTASES; CARCINOMAS; EXPRESSION; ANTIGEN; CELLS;
Keywords:
BREAST CANCER; CHICK EMBRYO LECTIN; S-LAC LECTIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
C. Henou et al., "ASSOCIATION OF N-ACETYLLACTOSAMINE WITH TUMOR PROGRESSION IN HUMAN BREAST-CANCER - A STUDY USING A 16 KDA CHICK-EMBRYO LECTIN", INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 1(4), 1998, pp. 771-775

Abstract

This study documents modifications in the expression and the cellulardistribution of binding sites for a 16 kDa chick embryo lectin (CL16-BS) in breast cancer. This lectin binds preferentially to terminal andpenultimate N-acetyllactosamine residues (Ga1 beta 1-4GlcNAc). BS density and distribution, studied by lectin binding followed by indirect immunofluorescence, were compared in normal breast tissues and 45 invasive carcinomas (lobular and ductal). Increased number of fluorescent epithelial cells (ETC+) were observed in normal ducts adjacent to lobular carcinomas and in tumors from both types when compared to normal glands. In ductal carcinomas, a significant diminution of ETC+ percentage was observed in the highest anatomopathological SBR grades: 32.7% in grade III, 80.8% in grade II and 66.5% in grade I (p<0.001). For both lobular and ductal carcinomas, ETC+ percentages were also positivelycorrelated with low versus high MSBR grades (p<0.002). The subcellular distribution of CL16-BS varied according to the tumor type and/or the histological grades. It was mostly membrane-associated in low SBR and MSBR grades (p<0.001 and p<0.01, respectively) and cytoplasm-associated in high grades (p<0.02 and p<0.05). Some of these parameters were also correlated with certain other clinicopathological factors, such as tumor size (p<0.02), high S-phase cell fraction (p<0.04 and p<0.03) and low density estrogen receptors (p<0.05). Diminution in CL16-BS density considered as indicators of tumor progression but not of metastasis.

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Documento generato il 25/10/20 alle ore 15:42:12