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Titolo:
DISTRIBUTION OF INTERLEUKIN-1-IMMUNOREACTIVE MICROGLIA IN CEREBRAL CORTICAL LAYERS - IMPLICATIONS FOR NEURITIC PLAQUE-FORMATION IN ALZHEIMERS-DISEASE
Autore:
SHENG JG; GRIFFIN WST; ROYSTON MC; MRAK RE;
Indirizzi:
JOHN L MCCLELLAN MEM VET ADM MED CTR,CTR GERIATR RES EDUC & CLIN,4300W 7TH ST LITTLE ROCK AR 72205 UNIV ARKANSAS MED SCI,CTR GERIATR RES EDUC & CLIN LITTLE ROCK AR 72205 UNIV ARKANSAS MED SCI,DEPT VET AFFAIRS MED CTR LITTLE ROCK AR 72205 UNIV ARKANSAS MED SCI,DEPT GERIATR LITTLE ROCK AR 72205 UNIV ARKANSAS MED SCI,DEPT PATHOL LITTLE ROCK AR 72205 IMPERIAL MED SCH,DEPT PSYCHIAT SHANGHAI PEOPLES R CHINA SHANGHAI MED UNIV 2,RUI JIN HOSP,DEPT NEUROL SHANGHAI PEOPLES R CHINA
Titolo Testata:
Neuropathology and applied neurobiology
fascicolo: 4, volume: 24, anno: 1998,
pagine: 278 - 283
SICI:
0305-1846(1998)24:4<278:DOIMIC>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-PRECURSOR; INTERLEUKIN-1; EXPRESSION; PATHOGENESIS; CELLS;
Keywords:
ALZHEIMERS DISEASE; BETA-AMYLOID PRECURSOR PROTEIN; CEREBRAL CORTICAL LAYERS; INTERLEUKIN-1; MICROGLIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
J.G. Sheng et al., "DISTRIBUTION OF INTERLEUKIN-1-IMMUNOREACTIVE MICROGLIA IN CEREBRAL CORTICAL LAYERS - IMPLICATIONS FOR NEURITIC PLAQUE-FORMATION IN ALZHEIMERS-DISEASE", Neuropathology and applied neurobiology, 24(4), 1998, pp. 278-283

Abstract

Activated microglia overexpressing interleukin-1 (IL-1) are prominentneuropathological features of Alzheimer's disease. We used computerized image analysis to determine the number of IL-1 alpha-immunoreactive(IL-1 alpha(+)) microglia in cytoarchitectonic layers of parahippocampal gyrus (Brodmann's area 28) of Alzheimer and control patients, For cortical layers I and II, the numbers of IL-1 alpha(+) microglia were similar in Alzheimer and control patients, For layers III-VI, the numbers of IL-1 alpha(+) microglia were higher than that seen in layers I-II for both Alzheimer and control patients, Moreover, for layers III-VI, the number of IL-1 alpha(+) microglia in Alzheimer patients was significantly greater than that: in control patients (relative Alzheimer values of threefold for layer III-V and twofold for layer VI; P < 0.05in each case). The cortical laminar distribution of IL-1 alpha(+) microglia in Alzheimer patients correlated with the cortical laminar distribution of beta-amyloid precursor protein-immunoreactive (beta-APP(+)) neuritic plaques found in Alzheimer patients (r = 0.99, P < 0.005), Moreover, the cortical laminar distribution of IL-1 alpha(+) microgliain control patients also correlated with the cortical laminar distribution of beta-APP(+) neuritic plaques found in Alzheimer patients (r =0.91, P < 0.05), These correlations suggest that pre-existing laminardistribution patterns of IL-1 alpha(+) microglia (i.e. that seen in control patients) are important in determining the observed laminar distribution of beta-APP(+) neuritic plaques in Alzheimer patients, Thesefindings provide further support for our hypothesis that IL-1 is a key driving force in neuritic plaque formation in Alzheimer's disease.

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Documento generato il 01/04/20 alle ore 10:20:59