Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
NALOXONE DOES NOT ALTER THE REGULATED DECREASE IN CORE TEMPERATURE DURING HYPOXEMIA IN GUINEA-PIGS
Autore:
CRISANTI KC; FEWELL JE;
Indirizzi:
UNIV CALGARY,HLTH SCI CTR,DEPT PHYSIOL & BIOPHYS,HERITAGE MED RES BLDG 206,3330 HOSP DR NW CALGARY AB T2N 4N1 CANADA UNIV CALGARY,HLTH SCI CTR,DEPT PHYSIOL & BIOPHYS CALGARY AB T2N 4N1 CANADA
Titolo Testata:
Journal of applied physiology (1985)
fascicolo: 3, volume: 85, anno: 1998,
pagine: 1150 - 1159
SICI:
8750-7587(1998)85:3<1150:NDNATR>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTNATAL MATURATION; METABOLIC RESPONSES; AMBIENT-TEMPERATURE; DENERVATED RATS; SET-POINT; HYPOXIA; OPIOIDS; PIGLETS; BRAIN; DIPRENORPHINE;
Keywords:
AUTONOMIC THERMOREGULATION; BEHAVIORAL THERMOREGULATION; CORE TEMPERATURE; ENDOGENOUS OPIOIDS; GUINEA PIGS; HYPOXEMIA; POSTNATAL MATURATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
K.C. Crisanti e J.E. Fewell, "NALOXONE DOES NOT ALTER THE REGULATED DECREASE IN CORE TEMPERATURE DURING HYPOXEMIA IN GUINEA-PIGS", Journal of applied physiology (1985), 85(3), 1998, pp. 1150-1159

Abstract

In newborns and adults of a number of species, exposure to acute hypoxemia produces a ''regulated'' decrease in core temperature, the mechanism of which is unknown. The present experiments were carried out in chronically instrumented newborn (5-10 days of age; n = 59) and older (25-30 days of age; n = 61) guinea pigs to test the hypothesis that the endogenous opioids mediate this regulated decrease in core temperature. During an experiment, core temperature, oxygen consumption, and selected ambient temperature were measured in a thermocline (linear temperature gradient of 10-40 degrees C) during a control period of normoxemia, an experimental period of normoxemia or hypoxemia (inspired oxygen fraction 0.10), and during a recovery period of normoxemia following an intraperitoneal injection of naloxone hydrochloride (a nonspecific opioid antagonist; 1, 2, or 4 mg/kg) or vehicle. Naloxone did not significantly alter basal core temperature or the core temperature response to acute hypoxemia in newborn or older guinea pigs. Naloxone did, however, decrease basal oxygen consumption in newborn and older guineapigs and altered the thermoregulatory effector mechanism used to decrease core temperature during hypoxemia in the newborn guinea pigs. Ourdata do not, support the hypothesis that the endogenous opioids mediate the regulated decrease in core temperature that occurs in newborn and older guinea pigs during exposure to acute hypoxemia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 20:11:16