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Titolo:
THE INFLUENCE OF INTESTINAL ISCHEMIA AND REPERFUSION ON BIDIRECTIONALINTESTINAL BARRIER PERMEABILITY, CELLULAR MEMBRANE INTEGRITY, PROTEINASE-INHIBITORS, AND CELL-DEATH IN RATS
Autore:
SUN ZW; WANG XD; DENG XM; LASSON A; WALLEN R; HALLBERG E; ANDERSSON R;
Indirizzi:
UNIV LUND HOSP,DEPT SURG S-22158 LUND SWEDEN UNIV LUND HOSP,DEPT SURG S-22158 LUND SWEDEN MALMO UNIV HOSP,DEPT SURG LUND SWEDEN LUND UNIV,DEPT ZOOL,DIV ELECT MICROSCOPY S-22362 LUND SWEDEN
Titolo Testata:
Shock
fascicolo: 3, volume: 10, anno: 1998,
pagine: 203 - 212
SICI:
1073-2322(1998)10:3<203:TIOIIA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAJOR LIVER RESECTION; BACTERIAL TRANSLOCATION; C1-ESTERASE INHIBITOR; OXYGEN RADICALS; ORGAN FAILURE; INJURY; APOPTOSIS; DYSFUNCTION; MODULATION; INDUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
Z.W. Sun et al., "THE INFLUENCE OF INTESTINAL ISCHEMIA AND REPERFUSION ON BIDIRECTIONALINTESTINAL BARRIER PERMEABILITY, CELLULAR MEMBRANE INTEGRITY, PROTEINASE-INHIBITORS, AND CELL-DEATH IN RATS", Shock, 10(3), 1998, pp. 203-212

Abstract

Intestinal ischemia and reperfusion injury (I/R) is probably involvedin the pathogenesis of intestinal barrier dysfunction, associated with the concomitant translocation of enteric bacteria and toxins and thepotential development of multiple organ failure. The intestinal endothelial and epithelial layers play a major role preventing the entry oftoxic substances from the gut, but the influence of protease-antiprotease systemic balance on these barrier functions and the relationship between epithelial DNA synthesis, apoptosis, and endothelial and epithelial barrier macromolecule permeability are not fully investigated. Endothelial and epithelial barrier macromolecular permeability, epithelial DNA synthesis, the endothelial and epithelial plasma membrane system, apoptosis and oncosis, plasma levels of proteinase inhibitors, andproenzymes were measured in rats subjected to 20 and 40 min intestinal ischemia and 1, 3, 6, or 12 h reperfusion. Endothelial permeability increased after both 20 and 40 min intestinal ischemia, Epithelial permeability significantly increased during 1-6 h reperfusion after 20 min ischemia and during 1-12 h reperfusion after 40 min ischemia. Epithelial DNA synthesis increased in animals with 20 min ischemia followed by 12 h reperfusion. Plasma levels of prekallikrein, C1-esterase inhibitor, and alpha 1-macroglobulin were significantly lower following both 20 and 40 min ischemia from 3 h reperfusion and on. Apoptotic epithelial cells significantly increased in animals subjected to 20 min ischemia followed by 12 h reperfusion. The severity of reperfusion injury in the intestinal endothelial and epithelial barrier seems to correlate with the period of ischemia and the pathway of cell damage and death, together with proteinase-antiproteinase imbalance.

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Documento generato il 09/04/20 alle ore 07:32:03