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Titolo:
EVIDENCE SUGGESTING THE INVOLVEMENT OF HEMATOPOIETIC STEM-CELLS IN THE PATHOGENESIS OF IGA NEPHROPATHY
Autore:
IMASAWA T; UTSUNOMIYA Y; KAWAMURA T; NAGASAWA R; MARUYAMA N; SAKAI O;
Indirizzi:
JIKEI UNIV,SCH MED,DEPT MICROBIOL,MINATO KU,3-25-8 NISHI SHINBASHI TOKYO 1058461 JAPAN JIKEI UNIV,SCH MED,DEPT INTERNAL MED,MINATO KU TOKYO 1058461 JAPAN SAITAMA MED SCH,MED CTR,DIV HEMODIALYSIS KAWAGOE SAITAMA 350 JAPAN TOKYO METROPOLITAN INST GERONTOL,DEPT MOL PATHOL,ITABASHI KU TOKYO 173 JAPAN
Titolo Testata:
Biochemical and biophysical research communications (Print)
fascicolo: 3, volume: 249, anno: 1998,
pagine: 605 - 611
SICI:
0006-291X(1998)249:3<605:ESTIOH>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; AUTOIMMUNE-DISEASES; POLYMERIC IGA; MESSENGER-RNA; DDY MICE; DEPOSITION; CLEARANCE; MODEL; BLOOD; RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
T. Imasawa et al., "EVIDENCE SUGGESTING THE INVOLVEMENT OF HEMATOPOIETIC STEM-CELLS IN THE PATHOGENESIS OF IGA NEPHROPATHY", Biochemical and biophysical research communications (Print), 249(3), 1998, pp. 605-611

Abstract

To investigate the role of hematopoietic stem cells in the pathogenesis of IgA nephropathy, T-cell-depleted bone marrow cells hom IgA nephropathy-prone ddY mice were transplanted into C57BL/6j (B6) mice pretreated with cyclophosphamide. In the 12th week after bone marrow transplantation, transplanted bone marrow cells had successfully regenerated. In B6 recipients of T-cell-depleted allogeneic bone marrow cells fromddY mice ([ddY-->B6]), mesangial IgA and C3 deposits were significantly more intense than those in B6 mice receiving syngeneic bone marrow cells of B6 mice ([B6-->B6]). The serum IgA level in [ddY-->B6] mice was higher than that in [B6-->B6] mice. Molecular profile analysis of serum IgA revealed that the serum concentration of macromolecular IgA was increased in [ddY-->B6], but not in [B6-->B6] mice. These data suggest that disorders programmed at the level of BMCs are involved in thepathogenesis of IgA nephropathy by increasing circulating levels of macromolecular IgA. (C) 1998 Academic Press.

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Documento generato il 03/07/20 alle ore 16:49:08