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Titolo:
BETA-CHEMOKINES AND NEUTRALIZING ANTIBODY-TITERS CORRELATE WITH STERILIZING IMMUNITY GENERATED IN HIV-1 VACCINATED MACAQUES
Autore:
HEENEY JL; TEEUWSEN VJP; VANGILS M; BOGERS WMJM; MORGHEN CD; RADAELLI A; BARNETT S; MOREIN B; AKERBLOM L; WANG YF; LEHNER T; DAVIS D;
Indirizzi:
BIOMED PRIMATE RES CTR,DEPT VIROL,LANGE KLEIWEG 157 NL-2288 GJ RIJSWIJK NETHERLANDS UNIV MILAN,DEPT PHARMACOL,MOL VIROL LAB I-10129 TURIN ITALY CHIRON CORP EMERYVILLE CA 94608 NATL VET INST,DEPT VIROL,CTR BIOMED S-75123 UPPSALA SWEDEN UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,DIV IMMUNOL LONDON SE1 9RT ENGLAND MED RES CTR,MOL IMMUNOPATHOL UNIT CAMBRIDGE CB2 2QH ENGLAND
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 18, volume: 95, anno: 1998,
pagine: 10803 - 10808
SICI:
0027-8424(1998)95:18<10803:BANACW>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; PROTECTIVE IMMUNITY; RHESUS MACAQUES; T-CELLS; INFECTION; CHIMPANZEES; TYPE-1; ENVELOPE; CHALLENGE; GP120;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
J.L. Heeney et al., "BETA-CHEMOKINES AND NEUTRALIZING ANTIBODY-TITERS CORRELATE WITH STERILIZING IMMUNITY GENERATED IN HIV-1 VACCINATED MACAQUES", Proceedings of the National Academy of Sciences of the United Statesof America, 95(18), 1998, pp. 10803-10808

Abstract

One of the obstacles to AIDS vaccine development is the variability of HIV-1 within individuals and within infected populations, enabling viral escape from highly specific vaccine induced immune responses. An understanding of the different immune mechanisms capable of inhibitingHIV infection may be of benefit in the eventual design of vaccines effective against HIV-1 variants. To study this we first compared the immune responses induced in Rhesus monkeys by using two different immunization strategies based on the same vaccine strain of HIV-1, We then utilized a chimeric simian/HIV that expressed the envelope of a dual tropic HIV-1 escape variant isolated from a later time point from the same patient from which the vaccine strain was isolated. Upon challenge,one vaccine group was completely protected from infection, whereas all of the other vaccinees and controls became infected. Protected macaques developed highest titers of heterologous neutralizing antibodies, and consistently elevated HIV-1-specific T helper responses. Furthermore, only protected animals had markedly increased concentrations of RANTES, macrophage inflammatory proteins 1 alpha and 1 beta produced by circulating CD8(+) T cells. These results suggest that vaccine strategies that induce multiple effector mechanisms in concert with beta-chemokines may be desired in the generation of protective immune responsesby HIV-1 vaccines.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/10/20 alle ore 00:42:01