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Titolo:
2 MODES OF TRANSVECTION - ENHANCER ACTION IN TRANS AND BYPASS OF A CHROMATIN INSULATOR IN CIS
Autore:
MORRIS JR; CHEN JL; GEYER PK; WU CT;
Indirizzi:
HARVARD UNIV,SCH MED,DEPT GENET,200 LONGWOOD AVE BOSTON MA 02115 HARVARD UNIV,SCH MED,DEPT GENET BOSTON MA 02115 UNIV IOWA,DEPT BIOCHEM IOWA CITY IA 52242
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 18, volume: 95, anno: 1998,
pagine: 10740 - 10745
SICI:
0027-8424(1998)95:18<10740:2MOT-E>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
DROSOPHILA-WHITE GENE; ZINC-FINGER PROTEIN; REGULATORY ELEMENTS; TRANSCRIPTIONAL ENHANCERS; PROMOTER INTERACTIONS; TRANSPOSABLE ELEMENT; ULTRABITHORAX GENE; MOLECULAR ANALYSIS; BITHORAX COMPLEX; YELLOW GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
71
Recensione:
Indirizzi per estratti:
Citazione:
J.R. Morris et al., "2 MODES OF TRANSVECTION - ENHANCER ACTION IN TRANS AND BYPASS OF A CHROMATIN INSULATOR IN CIS", Proceedings of the National Academy of Sciences of the United Statesof America, 95(18), 1998, pp. 10740-10745

Abstract

Ed Lewis introduced the term ''transvection'' in 1954 to describe mechanisms that can cause the expression of a gene to be sensitive to theproximity of its homologue. Transvection since has been reported at an increasing number of loci in Drosophila, where homologous chromosomes are paired in somatic tissues, as well as at loci in other organisms. At the Drosophila yellow gene, transvection can explain intragenic complementation involving the yellow(2) allele (y(2)). Here, transvection was proposed to occur by enhancers of one allele acting in trans onthe promoter of a paired homologue. In this report, we describe two yellow alleles that strengthen this model and reveal an unexpected, second mechanism for transvection. Data suggest that, in addition to enhancer action in trans, transvection can occur by enhancer bypass of a chromatin insulator in cis. We propose that bypass results from the topology of paired genes. Finally, transvection at yellow can occur in genotypes not involving y(2), implying that it is a feature of yellow itself and not an attribute of one particular allele.

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Documento generato il 21/09/20 alle ore 08:14:47