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Titolo:
ENDOTHELIN ETB RECEPTORS COUNTERACT VENOCONSTRICTOR EFFECTS OF ENDOTHELIN-1 IN ANESTHETIZED RATS
Autore:
PALACIOS B; LIM SL; PANG CCY;
Indirizzi:
UNIV BRITISH COLUMBIA,FAC MED,DEPT PHARMACOL & THERAPEUT,2176 HLTH SCI MALL VANCOUVER BC V6T 1Z3 CANADA UNIV BRITISH COLUMBIA,FAC MED,DEPT PHARMACOL & THERAPEUT VANCOUVER BCV6T 1Z3 CANADA
Titolo Testata:
Life sciences (1973)
fascicolo: 14, volume: 63, anno: 1998,
pagine: 1239 - 1249
SICI:
0024-3205(1998)63:14<1239:EERCVE>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
CIRCULATORY FILLING PRESSURE; SMOOTH-MUSCLE CONTRACTION; VASCULAR-RESPONSES; VENOUS RESISTANCES; SELECTIVE AGONIST; NITRIC-OXIDE; B-RECEPTOR; ANTAGONISTS; ARTERIAL; CELLS;
Keywords:
ENDOTHELIN-1; ETB-RECEPTOR AGONIST; ENDOTHELIN RECEPTOR ANTAGONIST; MEAN CIRCULATORY FILLING PRESSURE; VENOUS RESISTANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
B. Palacios et al., "ENDOTHELIN ETB RECEPTORS COUNTERACT VENOCONSTRICTOR EFFECTS OF ENDOTHELIN-1 IN ANESTHETIZED RATS", Life sciences (1973), 63(14), 1998, pp. 1239-1249

Abstract

The inhibitory effects of BQ 788 (3 mg/kg, i.v., ETB-receptor antagonist) on endothelin-1 (ET-1)- or IRL 1620 (ETB-receptor agonist)-induced changes in mean arterial pressure (MAP), mean circulatory filling pressure (MCFP, driving force of venous return), arterial resistance (R-A), venous resistance (R-V) and cardiac output (CO) were characterizedin 6 groups of pentobarbital-anesthetized rats. ET-1 or IRL 1620 (0.5, 1 and 2 nmol/kg, i.v.) dose-dependently increased MAP, R-A, R-V and MCFP and decreased CO. Maximum changes in R-A, R-V and CO elicited by ET-1 were greater than those by IRL 1620. Equimolar doses of ET-1 and IRL 1620 also caused similar initial transient decreases in MAP. BQ 788 alone slightly elevated MCFP, but did not alter other variables: TheETB-blocker abolished all changes elicited by IRL 1620, but only partially inhibited its responses on MCFP, showing the presence of BQ 788-insensitive receptors. BQ 788 also abolished ET-1's depressor response, partially inhibited its effect on MCFP, and markedly augmented its effects on R-A, R-V and CO. Thus, ETB-receptors counteract the sustained constrictor effects of ET-1 on arterial and venous resistance vessels. Our results indicate a substantial arterial and venous dilator rolefor ETB-receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 12:58:41