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Titolo:
INTERNAL CALVARIAL BONE DISTRACTION IN RABBITS WITH DELAYED-ONSET CORONAL SUTURE SYNOSTOSIS
Autore:
LOSKEN HW; MOONEY MP; ZOLDOS J; TSCHAKALOFF A; BURROWS AM; SMITH TD; COOPER GM; KAPUCU MR; SIEGEL MI;
Indirizzi:
3705 5TH AVE PITTSBURGH PA 15213 UNIV PITTSBURGH,DEPT ANAT & HISTOL PITTSBURGH PA 15260 UNIV PITTSBURGH,DEPT ANTHROPOL PITTSBURGH PA 15260 UNIV PITTSBURGH,DEPT PLAST & RECONSTRUCT SURG PITTSBURGH PA 15260 UNIV PITTSBURGH,DEPT ORTHODONT PITTSBURGH PA 15260 SLIPPERY ROCK UNIV,DEPT PHYS THERAPY SLIPPERY ROCK PA 16057
Titolo Testata:
Plastic and reconstructive surgery
fascicolo: 4, volume: 102, anno: 1998,
pagine: 1109 - 1119
SICI:
0032-1052(1998)102:4<1109:ICBDIR>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
MANDIBULAR DISTRACTION; CALLUS DISTRACTION; RIGID FIXATION; CRANIAL VAULT; GROWTH; CRANIOSYNOSTOSIS; EXPANSION; SKULL; OSTEOTOMIES; SEGMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
H.W. Losken et al., "INTERNAL CALVARIAL BONE DISTRACTION IN RABBITS WITH DELAYED-ONSET CORONAL SUTURE SYNOSTOSIS", Plastic and reconstructive surgery, 102(4), 1998, pp. 1109-1119

Abstract

Recent studies have identified a subpopulation of craniosynostotic individuals who exhibit progressive or delayed-onset synostosis and mildcraniofacial growth abnormalities. These individuals may be good candidates for nonextirpation, distraction osteogenesis therapy. The present study was designed to test this hypothesis by using internal calvarial bone distraction in a rabbit model with familial delayed-onset craniosynostosis. Data were collected from 159 rabbits:71 normal controls, 72 with delayed-onset coronal suture synostosis, 8 with delayed-onset coronal suture synostosis and coronal suturectomy, and 8 with delayed-onset coronal suture synostosis and distraction. At 10 days of age, all rabbits had amalgam markers placed on both sides of the frontonasal, coronal, and anterior lambdoidal sutures. At 25 days of age, correction was accomplished through either a 5-mm-wide suturectomy or distraction osteogenesis. An internal distraction appliance was fixed to thefrontal and parietal bones and percutaneously and intermittently activated at an average of 0.10 mm/day for 42 days (4.11 mm total). Serialradiographs were taken at 10, 25, 42, and 84 days of age. Results revealed that rabbits with delayed-onset synostosis had significantly (p < 0.01) reduced coronal suture growth rates (0.04 mm/day) compared with the other three groups (0.07 mm/day). Rabbits with suturectomy and rabbits with distraction showed similar coronal suture responses. However, from 42 to 84 days of age, rabbits with distraction showed reducedgrowth at the vault sutures and abnormal growth patterns in cranial vault width, cranial vault shape, and cranial base angulation compared with the other three groups. Results demonstrated that, although the normal coronal suture growth rate was maintained in rabbits with delayed-onset synostosis using intermittent distraction osteogenesis, normaladult craniofacial structure was not achieved. Such anomalous growth was probably a result of altered growth Vectors and compressive forcesat adjacent sutures during distraction. These findings suggest that distraction osteogenesis without corticotomy may be a treatment alternative in individuals with progressive, delayed-onset synostosis,but that internal appliances that generate low-level, continuous distractive forces should be investigated and developed.

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Documento generato il 03/07/20 alle ore 01:00:53