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Titolo:
PHENCYCLIDINE INTERFERES WITH THE HIPPOCAMPAL GATING OF NUCLEUS-ACCUMBENS NEURONAL-ACTIVITY IN-VIVO
Autore:
ODONNELL P; GRACE AA;
Indirizzi:
UNIV PITTSBURGH,DEPT NEUROSCI PITTSBURGH PA 15260 UNIV PITTSBURGH,DEPT NEUROSCI PITTSBURGH PA 15260 UNIV PITTSBURGH,DEPT PSYCHIAT PITTSBURGH PA 15260
Titolo Testata:
Neuroscience
fascicolo: 4, volume: 87, anno: 1998,
pagine: 823 - 830
SICI:
0306-4522(1998)87:4<823:PIWTHG>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED STEREOTYPED BEHAVIOR; PREPULSE INHIBITION; LOCOMOTOR-ACTIVITY; INDUCED DEFICITS; SOCIAL-BEHAVIOR; BASAL GANGLIA; SCHIZOPHRENIA; RAT; ANTAGONISM; NEUROLEPTICS;
Keywords:
PCP; SCHIZOPHRENIA; ELECTROPHYSIOLOGY; SUBICULUM; IN VIVO INTRACELLULAR RECORDINGS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
P. Odonnell e A.A. Grace, "PHENCYCLIDINE INTERFERES WITH THE HIPPOCAMPAL GATING OF NUCLEUS-ACCUMBENS NEURONAL-ACTIVITY IN-VIVO", Neuroscience, 87(4), 1998, pp. 823-830

Abstract

The N-methyl-D-aspartate channel blocker phencyclidine is known to induce psychotic episodes in normal subjects and exacerbate psychosis inschizophrenics; however, its site of action is not clear. The prefrontal cortex, hippocampus, and basal ganglia are brain regions that appear to play a role in the pathophysiology of schizophrenia, and therefore are the most likely to be involved in the psychotomimetic action ofphencyclidine. In this study, systemic administration of phencyclidine reduced the frequency and duration of the spontaneously occurring depolarized plateaus observed in the membrane potential of accumbens neurons recorded intracellularly in vivo. Furthermore, recordings from rats pretreated with phencyclidine yielded proportionately fewer neuronsshowing depolarized events compared with untreated animals. These results suggest that phencyclidine may interfere with the generation of the depolarized (''up'') slate of the accumbens neuron membrane potential, which we had previously shown is dependent upon hippocampal input and is necessary for action potential discharge in these neurons. Thisaction of phencyclidine is proposed to impair the how of cortical information through the nucleus accumbens, and thereby mimic the consequences of the hippocampal deficit proposed to contribute to the pathophysiology of schizophrenia. (C) 1998 IBRO. Published by Elsevier ScienceLtd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 21:45:19