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Titolo:
EXPRESSION AND PHYSIOLOGICAL ACTIONS OF NEUROPEPTIDE-Y IN GUINEA-PIG PARASYMPATHETIC CARDIAC GANGLIA
Autore:
KENNEDY AL; HARAKALL SA; LYNCH SW; BRAAS KM; HARDWICK JC; MAWE GM; PARSONS RL;
Indirizzi:
UNIV VERMONT,COLL MED,DEPT ANAT & NEUROBIOL BURLINGTON VT 05405 UNIV VERMONT,COLL MED,DEPT ANAT & NEUROBIOL BURLINGTON VT 05405
Titolo Testata:
Journal of the autonomic nervous system
fascicolo: 2-3, volume: 71, anno: 1998,
pagine: 190 - 195
SICI:
0165-1838(1998)71:2-3<190:EAPAON>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATING POLYPEPTIDE PACAP; INTRACARDIAC NEURONS; INTRINSIC NEURONS; HEART-RATE; IMMUNOREACTIVITY; CATECHOLAMINE; NERVES; INNERVATION; SECRETION;
Keywords:
GUINEA PIG; CARDIAC GANGLIA; NEUROPEPTIDE Y; NEUROPEPTIDE TYROSINE; PARASYMPATHETIC NEURONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
A.L. Kennedy et al., "EXPRESSION AND PHYSIOLOGICAL ACTIONS OF NEUROPEPTIDE-Y IN GUINEA-PIG PARASYMPATHETIC CARDIAC GANGLIA", Journal of the autonomic nervous system, 71(2-3), 1998, pp. 190-195

Abstract

Guinea pig atrial whole mount preparations containing the parasympathetic cardiac ganglia were used to establish the expression, distribution and actions of neuropeptide Y (NPY) in atrial tissues. NPY-immunoreactive fibers densely innervated the atrial myocardium and blood vessels. Fibers containing NPY also innervated intrinsic parasympathetic cardiac neurons. Four percent of the cardiac neurons, identified using microtubule associated protein-2 antiserum, were NPY-positive. An endogenous source of NPY was confirmed with reverse transcription PCR whichdemonstrated the presence of proNPY mRNA. Sixty percent of the parasympathetic cardiac neurons were hyperpolarized by local application of NPY. NPY also decreased the amplitude and duration of the action potential after hyperpolarization in 60% of the neurons and decreased the fast excitatory postsynaptic potential in about 50% of the cells. Theseobservations indicate that NPY is anatomically positioned to directlyalter the output of the parasympathetic cardiac ganglia either by hyperpolarizing the cardiac neurons or by decreasing the fast synaptic input which drives individual neurons. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 11:30:33