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Titolo:
EFFECT OF GENERALIZED SYMPATHETIC ACTIVATION BY COLD PRESSOR TEST ON CEREBRAL HEMODYNAMICS IN HEALTHY HUMANS
Autore:
ROATTA S; MICIELI G; BOSONE D; LOSANO G; BINI R; CAVALLINI A; PASSATORE M;
Indirizzi:
UNIV TORINO,SCH MED,DEPT NEUROSCI,DIV PHYSIOL,CORSO RAFFAELLO 30 I-10126 TURIN ITALY UNIV TORINO,SCH MED,DEPT NEUROSCI,DIV PHYSIOL I-10126 TURIN ITALY UNIV TORINO,SCH MED,CTR INTERUNIV NEUROFISIOL DOLORE I-10126 TURIN ITALY UNIV PAVIA,SCH MED,C MONDINO FDN,DEPT NEUROL,STROKE UNIT I-27100 PAVIA ITALY
Titolo Testata:
Journal of the autonomic nervous system
fascicolo: 2-3, volume: 71, anno: 1998,
pagine: 159 - 166
SICI:
0165-1838(1998)71:2-3<159:EOGSAB>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRANIAL DOPPLER ULTRASOUND; BLOOD-FLOW REGULATION; CARDIOVASCULAR-RESPONSES; AUTOREGULATION DYNAMICS; ARTERIAL-HYPERTENSION; VELOCITY; STIMULATION; INNERVATION; STRESS; RAT;
Keywords:
SYMPATHETIC SYSTEM; CEREBRAL CIRCULATION; TRANSCRANIAL DOPPLER; COLD PRESSOR TEST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
S. Roatta et al., "EFFECT OF GENERALIZED SYMPATHETIC ACTIVATION BY COLD PRESSOR TEST ON CEREBRAL HEMODYNAMICS IN HEALTHY HUMANS", Journal of the autonomic nervous system, 71(2-3), 1998, pp. 159-166

Abstract

There is no general agreement regarding several aspects of the role of the sympathetic system on cerebral haemodynamics such as extent of effectiveness, operational range and site of action. This study was planned to identify the effect of a generalised sympathetic activation onthe cerebral haemodynamics in healthy humans before it is masked by secondary corrections, metabolic or myogenic in nature. A total of 35 healthy volunteers aged 20-35 underwent a 5 min lasting cold presser test (CPT) performed on their left hand. The cerebral blood flow (CBF) velocity in the middle cerebral arteries and arterial blood pressure were recorded with transcranial Doppler sonography and with a non-invasive finger-cuff method, respectively. The ratio of arterial blood pressure to mean blood velocity (ABP/V-m)() and Pulsatility Index (PI) werecalculated throughout each trial. CPT induced an increase in mean ABP(range 2-54 mmHg depending on the subject) and only a slight, though significant, increase in blood velocity in the middle cerebral artery (+2.4 and +4.4% on ipsi- and contralateral side, respectively). DuringCPT, the ratio ABP/V-m increased and PI decreased in all subjects on both sides. These changes began simultaneously with the increase in blood pressure. The increase in ABP/V-m ratio is attributed to an increase in the cerebrovascular resistance, while the concomitant reduction in PI is interpreted as due to the reduction in the compliance of the middle cerebral artery. The results suggest that generalised increasesin the sympathetic discharge, causing increases in ABP, can prevent concomitant increases in CBF by acting on both small resistance and large compliant vessels. This effect is also present when a slight increase in blood pressure occurs, which suggests a moderate increase in thesympathetic discharge, i.e. when ABP remains far below the upper limit of CBF autoregulation. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 21:12:45