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Titolo:
IMMUNOREACTIVITY OF SERA TO A PEPTIDE DERIVED FROM THE SEROTONIN 5-HT1A RECEPTOR IN A GROUP OF CHILDREN WITH DEVELOPMENTAL DISORDERS - POSSIBLE ROLE IN NON-AUTISTIC EPILEPSY
Autore:
VERDOT L; GARREAU B; BARTHELEMY C; MARTINEAU J; FERRERDIMARTINO M; MUH JP; HOEBEKE J;
Indirizzi:
FAC PHARM TOURS,CJF 93-09,31 AVE MONGE F-37200 TOURS FRANCE FAC PHARM TOURS F-37200 TOURS FRANCE CHU BRETONNEAU,INSERM,U316 F-37044 TOURS FRANCE LAB ENZYMOL & CHIM PROT F-37032 TOURS FRANCE
Titolo Testata:
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
fascicolo: 1, volume: 1, anno: 1998,
pagine: 185 - 189
SICI:
1107-3756(1998)1:1<185:IOSTAP>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIBODIES; HYPERSEROTONINEMIA; PROTEINS; FAMILY;
Keywords:
AUTOANTIBODIES; AUTISM; EPILEPSY; 5-HT1A RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
L. Verdot et al., "IMMUNOREACTIVITY OF SERA TO A PEPTIDE DERIVED FROM THE SEROTONIN 5-HT1A RECEPTOR IN A GROUP OF CHILDREN WITH DEVELOPMENTAL DISORDERS - POSSIBLE ROLE IN NON-AUTISTIC EPILEPSY", INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 1(1), 1998, pp. 185-189

Abstract

The presence of autoantibodies against the serotoninergic 5-HT1A receptor has been reported in serum from an autistic child using radioligand binding studies. It is now well established that, in cardiovasculardiseases with an autoimmune component, patients present in their seraautoantibodies directed against the second extracellular loop of someG-protein coupled membrane receptors. We thus investigated by an enzyme-immunoassay method the presence of anti-5-HT1A receptor antibodies in sera of children with developmental disorders using synthetic peptides corresponding to the first and the second extracellular loops of this receptor. The population of children with developmental disorders was divided in autistic children with or without EEG abnormalities, and in non-autistic children with or without EEG abnormalities. We foundthat 6 out of 10 sera of non-autistic children with an abnormal EEG recognized the second extracellular loop of the 5-HT1A receptor. This is significantly higher than the other groups of children with developmental disorders or a healthy control group. These observations supportthe existence of an autoimmune component in epilepsy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 01:19:43